ArticleGenetics2013
Inferences of demography and selection in an African population of Drosophila melanogaster.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Demographic History of the Human Commensal Drosophila melanogaster.Genome biology and evolution · 2019Article
- The Demographic History of African Drosophila melanogaster.Genome biology and evolution · 2018Article
- The Role of Phylogenetically Conserved Elements in Shaping Patterns of Human Genomic Diversity.Molecular biology and evolution · 2018Article
- Genetic Diversity on the Sex Chromosomes.Genome biology and evolution · 2018Review
- Detecting Long-Term Balancing Selection Using Allele Frequency Correlation.Molecular biology and evolution · 2017Article
- Molecular Population Genetics.Genetics · 2017Review
- Adaptive evolution of genes involved in the regulation of germline stem cells in Drosophila melanogaster and D. simulans.G3 (Bethesda, Md.) · 2015Article
- Sampling strategies for frequency spectrum-based population genomic inference.BMC evolutionary biology · 2014Article
- Human-induced evolution caught in action: SNP-array reveals rapid amphi-atlantic spread of pesticide resistance in the salmon ecotoparasite Lepeophtheirus salmonis.BMC genomics · 2014Article
- Robust forward simulations of recurrent hitchhiking.Genetics · 2014Article
- Origin and demographic history of the endemic Taiwan spruce (Picea morrisonicola).Ecology and evolution · 2013Article
- Fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome.Genetics · 2013Article
- Surprising differences in the variability of Y chromosomes in African and cosmopolitan populations of Drosophila melanogaster.Genetics · 2013Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
It remains a central problem in population genetics to infer the past action of natural selection, and these inferences pose a challenge because demographic events will also substantially affect patterns of polymorphism and divergence. Thus it is imperative to explicitly model the underlying demographic history of the population whenever making inferences about natural selection. In light of the considerable interest in adaptation in African populations of Drosophila melanogaster, which are considered ancestral to the species, we generated a large polymorphism data set representing 2.1 Mb from each of 20 individuals from a Ugandan population of D. melanogaster. In contrast to previous inferences of a simple population expansion in eastern Africa, our demographic modeling of this ancestral population reveals a strong signature of a population bottleneck followed by population expansion, which has significant implications for future demographic modeling of derived populations of this species. Taking this more complex underlying demographic history into account, we also estimate a mean X-linked region-wide rate of adaptation of 6 × 10(-11)/site/generation and a mean selection coefficient of beneficial mutations of 0.0009. These inferences regarding the rate and strength of selection are largely consistent with most other estimates from D. melanogaster and indicate a relatively high rate of adaptation driven by weakly beneficial mutations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.