ArticleExperimental physiology2013
Thyroid hormone is required for growth adaptation to pressure load in the ovine fetal heart.
Article in Experimental physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Late gestation fetal hypothyroidism alters cell cycle regulation across multiple organ systems.BMC veterinary research · 2024Article
- Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny.American journal of physiology. Heart and circulatory physiology · 2023Article
- Developmental changes of the fetal and neonatal thyroid gland and functional consequences on the cardiovascular system.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Adaptive Responses of Thyroid Hormones, Insulin, and Glucose during Pregnancy and Lactation in Dairy Cows.Animals : an open access journal from MDPI · 2022Article
- The role of hormones and neurons in cardiomyocyte maturation.Seminars in cell & developmental biology · 2021Review
- Maternal nutrient restriction alters thyroid hormone dynamics in placentae of sheep having small for gestational age fetuses.Domestic animal endocrinology · 2021Article
- Endocrine Influence on Cardiac Metabolism in Development and Regeneration.Endocrinology · 2021Review
- Hormonal control of cardiac regenerative potential.Endocrine connections · 2021Review
- Thyroid hormone signaling and consequences for cardiac development.The Journal of endocrinology · 2019Review
- Scaling of cardiac morphology is interrupted by birth in the developing sheep Ovis aries.Journal of anatomy · 2019Article
- Right ventricular remodeling in response to volume overload in fetal sheep.American journal of physiology. Heart and circulatory physiology · 2019Article
- Evidence for hormonal control of heart regenerative capacity during endothermy acquisition.Science (New York, N.Y.) · 2019Article
- Cardiac myocyte proliferation and maturation near term is inhibited by early gestation maternal testosterone exposure.American journal of physiology. Heart and circulatory physiology · 2018Article
- Systemic arterial hypertension but not IGF-I treatment stimulates cardiomyocyte enlargement in neonatal lambs.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- IUGR impairs cardiomyocyte growth and maturation in fetal sheep.The Journal of endocrinology · 2018Article
- Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Thyroid hormone manipulation influences development of cardiovascular regulation in embryonic Pekin duck, Anas platyrhynchos domestica.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214.Scientific reports · 2017Article
- Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment.The Journal of endocrinology · 2016Review
- ANG II modulation of cardiac growth and remodeling in immature fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Thyroid hormone exerts broad effects on the adult heart, but little is known regarding the role of thyroid hormone in the regulation of cardiac growth early in development and in response to pathophysiological conditions. To address this issue, we determined the effects of fetal thyroidectomy on cardiac growth and growth-related gene expression in control and pulmonary-artery-banded fetal sheep. Fetal thyroidectomy (THX) and/or placement of a restrictive pulmonary artery band (PAB) were performed at 126 ± 1 days of gestation (term, 145 days). Four groups of animals [n = 5-6 in each group; (i) control; (ii) fetal THX; (iii) fetal PAB; and (iv) fetal PAB + THX] were monitored for 1 week prior to being killed. Fetal heart rate was significantly lower in the two THX groups compared with the non-THX groups, while mean arterial blood pressure was similar among groups. Combined left and right ventricle free wall + septum weight, expressed per kilogram of fetal weight, was significantly increased in PAB (6.27 ± 0.85 g kg(-1)) compared with control animals (4.72 ± 0.12 g kg(-1)). Thyroidectomy significantly attenuated the increase in cardiac mass associated with PAB (4.94 ± 0.13 g kg(-1)), while THX alone had no detectable effect on heart mass (4.95 ± 0.27 g kg(-1)). The percentage of binucleated cardiomyocytes was significantly decreased in THX and PAB +THX groups (∼16%) compared with the non-THX groups (∼27%). No differences in levels of activated Akt, extracellular signal-regulated kinase or c-Jun N-terminal kinase were detected among the groups. Markers of cellular proliferation but not apoptosis or expression of growth-related genes were lower in the THX and THX+ PAB groups relative to thyroid-intact animals. These findings suggest that in the late-gestation fetal heart, thyroid hormone has important cellular growth functions in both physiological and pathophysiological states. Specifically, thyroid hormone is required for adaptive fetal cardiac growth in response to pressure overload.
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