ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2012
Mechanical discoordination increases continuously after the onset of left bundle branch block despite constant electrical dyssynchrony in a computational model of cardiac electromechanics and growth.
Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 40 citations in OpenAlex.
- A multiscale model of the cardiovascular system that regulates arterial pressure via closed loop baroreflex control of chronotropism, cell-level contractility, and vascular tone.Biomechanics and modeling in mechanobiology · 2022Article
- The Balance between the Left and Right Ventricular Deformation Evaluated by Speckle Tracking Echocardiography Is a Great Predictor of the Major Adverse Cardiac Event in Patients with Pulmonary Hypertension.Diagnostics (Basel, Switzerland) · 2022Article
- Computational models of cardiac hypertrophy.Progress in biophysics and molecular biology · 2021Review
- Predictions of hypertrophy and its regression in response to pressure overload.Biomechanics and modeling in mechanobiology · 2020Article
- Effects of Mechanical Dyssynchrony on Coronary Flow: Insights From a Computational Model of Coupled Coronary Perfusion With Systemic Circulation.Frontiers in physiology · 2020Article
- A publicly available virtual cohort of four-chamber heart meshes for cardiac electro-mechanics simulations.PloS one · 2020Article
- A rule-based method for predicting the electrical activation of the heart with cardiac resynchronization therapy from non-invasive clinical data.Medical image analysis · 2019Article
- Model of Anisotropic Reverse Cardiac Growth in Mechanical Dyssynchrony.Scientific reports · 2019Article
- Multiscale Models of Cardiac Muscle Biophysics and Tissue Remodeling in Hypertrophic Cardiomyopathies.Current opinion in biomedical engineering · 2019Article
- Simulation of action potential propagation based on the ghost structure method.Scientific reports · 2019Article
- Computational models in cardiology.Nature reviews. Cardiology · 2019Review
- Predicting the Time Course of Ventricular Dilation and Thickening Using a Rapid Compartmental Model.Journal of cardiovascular translational research · 2018Article
- Computational Modeling for Cardiac Resynchronization Therapy.Journal of cardiovascular translational research · 2018Review
- Clinical Applications of Patient-Specific Models: The Case for a Simple Approach.Journal of cardiovascular translational research · 2018Article
- Modeling Pathologies of Diastolic and Systolic Heart Failure.Annals of biomedical engineering · 2016Article
- Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module.PLoS computational biology · 2015Article
- Myocardial motion and deformation patterns in an experimental swine model of acute LBBB/CRT and chronic infarct.The international journal of cardiovascular imaging · 2014Article
- Understanding the mechanisms amenable to CRT response: from pre-operative multimodal image data to patient-specific computational models.Medical & biological engineering & computing · 2013Review
- Electromechanical dyssynchrony and resynchronization of the failing heart.Circulation research · 2013Review
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
aimsTo test whether a functional growth law leads to asymmetric hypertrophy and associated changes in global and regional cardiac function when integrated with a computational model of left bundle branch block (LBBB). METHODS AND
resultsIn recent studies, we proposed that cardiac myocytes grow longer when a threshold of maximum fibre strain is exceeded and grow thicker when the smallest maximum principal strain in the cellular cross-sectional plane exceeds a threshold. A non-linear cardiovascular model of the beating canine ventricles was combined with the cellular growth law. After inducing LBBB, the ventricles were allowed to adapt in shape over time in response to mechanical stimuli. When subjected to electrical dyssynchrony, the combined model of ventricular electromechanics, haemodynamics, and growth led to asymmetric hypertrophy with a faster increase of wall mass in the left ventricular (LV) free wall (FW) than the septum, increased LV end-diastolic and end-systolic volumes, and decreased LV ejection fraction. Systolic LV pressure decreased during the acute phase of LBBB and increased at later stages. The relative changes of these parameters were similar to those obtained experimentally. Most of the dilation was due to radial and axial fibre growth, and hence altered shape of the LVFW.
conclusionOur previously proposed growth law reproduced measured dyssynchronously induced asymmetric hypertrophy and the associated functional changes, when combined with a computational model of the LBBB heart. The onset of LBBB leads to a step increase in LV mechanical discoordination that continues to increase as the heart remodels despite the constant electrical dyssynchrony.
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