ReviewCirculation research2012
Endothelial cells derived from nuclear reprogramming.
Review in Circulation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- A guide to cell-type-specific Cre mouse models in atherosclerosis: from background strains to future directions.Frontiers in cardiovascular medicine · 2026Review
- Vasculogenic skin reprogramming requires TET-mediated gene demethylation in fibroblasts for rescuing impaired perfusion in diabetes.Nature communications · 2024Article
- Review
- Blood vessels in a dish: the evolution, challenges, and potential of vascularized tissues and organoids.Frontiers in cardiovascular medicine · 2024Review
- Machine learning uncovers cell identity regulator by histone code.Nature communications · 2020Article
- NuclearCirculation · 2019Article
- Induced pluripotent stem cell-derived endothelial cells attenuate lipopolysaccharide-induced acute lung injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Environmental Specification of Pluripotent Stem Cell Derived Endothelial Cells Toward Arterial and Venous Subtypes.Frontiers in bioengineering and biotechnology · 2019Review
- Follistatin-Like 3 Enhances the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Facilitating β-Catenin Nuclear Translocation Through Inhibition of Glycogen Synthase Kinase-3β Activity.Stem cells (Dayton, Ohio) · 2018Article
- Initial Assessment of Variability of Responses to Toxicants in Donor-Specific Endothelial Colony Forming Cells.Frontiers in public health · 2018Article
- Regenerating the Cardiovascular System Through Cell Reprogramming; Current Approaches and a Look Into the Future.Frontiers in cardiovascular medicine · 2018Review
- Human Induced Pluripotent Stem Cell-Derived Endothelial Cells for Three-Dimensional Microphysiological Systems.Tissue engineering. Part C, Methods · 2017Article
- Quaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis.Stem cells (Dayton, Ohio) · 2017Article
- Article
- Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes.Frontiers in endocrinology · 2017Review
- Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells.Scientific reports · 2016Article
- Reprogramming towards endothelial cells for vascular regeneration.Genes & diseases · 2016Review
- Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo.Blood · 2016Article
- Mechanocompatible Polymer-Extracellular-Matrix Composites for Vascular Tissue Engineering.Advanced healthcare materials · 2016Article
- Transdifferentiation of Fibroblasts by Defined Factors.Cellular reprogramming · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The endothelium plays a pivotal role in vascular homeostasis, regulating the tone of the vascular wall, and its interaction with circulating blood elements. Alterations in endothelial functions facilitate the infiltration of inflammatory cells and permit vascular smooth muscle proliferation and platelet aggregation. Therefore, endothelial dysfunction is an early event in disease processes including atherosclerosis, and because of its critical role in vascular health, the endothelium is worthy of the intense focus it has received. However, there are limitations to studying human endothelial function in vivo, or human vascular segments ex vivo. Thus, methods for endothelial cell (EC) culture have been developed and refined. Recently, methods to derive ECs from pluripotent cells have extended the scientific range of human EC studies. Pluripotent stem cells may be generated, expanded, and then differentiated into ECs for in vitro studies. Constructs for molecular imaging can also be employed to facilitate tracking these cells in vivo. Furthermore, one can generate patient-specific ECs to study the effects of genetic or epigenetic alterations on endothelial behavior. Finally, there is the opportunity to apply these cells for vascular therapy. This review focuses on the generation of ECs from stem cells; their characterization by genetic, histological, and functional studies; and their translational applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.