ArticleSchizophrenia bulletin2014
Evaluating genetic counseling for family members of individuals with schizophrenia in the molecular age.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- The Efficacy of Genetic Counseling for Psychiatric Disorders: a Meta-Analysis.Journal of genetic counseling · 2017Pooled it
- A cluster randomized controlled trial of an online psychoeducational intervention for people with a family history of depression.BMC psychiatry · 2019Trial
- A pilot randomized clinical trial evaluating the impact of genetic counseling for serious mental illnesses.The Journal of clinical psychiatry · 2016Trial
- Protocol for a new family history of addiction density score to aid in the treatment of alcohol and substance use disorders.Drug and alcohol dependence reports · 2025Article
- Ethical and social issues in prediction of risk of severe mental illness: a scoping review and thematic analysis.BMC psychiatry · 2025Article
- Genetic counselling for psychiatric conditions: exploring current perceptions of family physicians and psychiatrists in Portugal.Journal of community genetics · 2025Article
- Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians' attitudes to sociocultural differences between patients across the globe.Translational psychiatry · 2022Review
- The impact of psychiatric disorders on caregivers: An integrative predictive model of burden, stigma, and well-being.Perspectives in psychiatric care · 2022Article
- Perceptions of causal attribution and attitudes to genetic testing among people with schizophrenia and their first-degree relatives.European journal of human genetics : EJHG · 2022Article
- In-vivo design feedback and perceived utility of a genetically-informed smoking risk tool among current smokers in the community.BMC medical genomics · 2021Article
- Assessing Stakeholder Perceptions of the Utility of Genetic Information for the Clinical Care of Mental Health Disorders: We Have a Will but Need to See the Way.Administration and policy in mental health · 2021Article
- Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map.Cold Spring Harbor perspectives in medicine · 2020Review
- Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review.Public health genomics · 2020Review
- International Society of Psychiatric Genetics Ethics Committee: Issues facing us.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Review
- Parkinson's Disease: Patients' Knowledge, Attitudes, and Interest in Genetic Counseling.Journal of genetic counseling · 2018Article
- Referrals to Mental Health Services: Exploring the Referral Process in Genetic Counseling.Journal of genetic counseling · 2018Article
- Receptiveness to participation in genetic research: A pilot study comparing views of people with depression, diabetes, or no illness.Journal of psychiatric research · 2017Article
- Genetic Counseling for Alcohol Addiction: Assessing Perceptions and Potential Utility in Individuals with Lived Experience and Their Family Members.Journal of genetic counseling · 2017Article
- Attitudes about Future Genetic Testing for Posttraumatic Stress Disorder and Addiction among Community-Based Veterans.Frontiers in psychiatry · 2017Article
- Neuropsychiatric aspects of 22q11.2 deletion syndrome: considerations in the prenatal setting.Prenatal diagnosis · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundMyths and concerns about the extent and meaning of genetic risk in schizophrenia may contribute to significant stigma and burden for families. Genetic counseling has long been proposed to be a potentially informative and therapeutic intervention for schizophrenia. Surprisingly, however, available data are limited. We evaluated a contemporary genetic counseling protocol for use in a community mental health-care setting by non-genetics professionals.
methodsWe used a pre-post study design with longitudinal follow-up to assess the impact of genetic counseling on family members of individuals with schizophrenia, where molecular testing had revealed no known clinically relevant genetic risk variant. We assessed the outcome using multiple measures, including standard items and scales used to evaluate genetic counseling for other complex diseases.
resultsOf the 122 family members approached, 78 (63.9%) actively expressed an interest in the study. Participants (n = 52) on average overestimated the risk of familial recurrence at baseline, and demonstrated a significant improvement in this estimate postintervention (P < .0001). This change was associated with an enduring decrease in concern about recurrence (P = .0003). Significant and lasting benefits were observed in other key areas, including increased knowledge (P < .0001) and a decreased sense of stigma (P = .0047). Endorsement of the need for genetic counseling was high (96.1%).
conclusionsThese results provide initial evidence of the efficacy of schizophrenia genetic counseling for families, even in the absence of individually relevant genetic test results or professional genetics services. The findings support the integration of contemporary genetic counseling for families into the general management of schizophrenia in the community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.