ArticleJournal of bacteriology2013
The σE pathway is involved in biofilm formation by Crohn's disease-associated adherent-invasive Escherichia coli.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Synthetic polymers promote cell aggregation and accelerate cathode-associated layer formation inBiofilm · 2026Article
- A host anti-amyloidogenic stomach-specific protein inhibits colonization and biofilm formation by adherent invasive Escherichia coli in the colon.Research square · 2026Article
- Integrated genomic and mutagenesis analysis of Pseudomonas argentinensis SA190 reveals mechanisms of plant root colonization and stress resilience.BMC microbiology · 2025Article
- Characterizing the Pathogenic Potential of Crohn's Disease-Associated Adherent-InvasiveEcoSal Plus · 2023Review
- Biofilms and Benign Colonic Diseases.International journal of molecular sciences · 2022Review
- Article
- The Physiological Functions of AbrB on Sporulation, Biofilm Formation and Carbon Source Utilization inBioengineering (Basel, Switzerland) · 2022Article
- Inactivation of the Pyrimidine BiosynthesisMicroorganisms · 2022Article
- Phylogrouping and characterization ofFrontiers in medicine · 2022Article
- Extracytoplasmic Function σ Factors as Tools for Coordinating Stress Responses.International journal of molecular sciences · 2021Review
- Dietary Emulsifiers Directly Impact Adherent-Invasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation.Cell reports · 2020Article
- Why the discovery of adherent-invasiveWorld journal of biological chemistry · 2020Review
- Structures and mechanism of transcription initiation by bacterial ECF factors.Nucleic acids research · 2019Article
- Maintaining Integrity Under Stress: Envelope Stress Response Regulation of Pathogenesis in Gram-Negative Bacteria.Frontiers in cellular and infection microbiology · 2019Review
- Phagocytosis and Epithelial Cell Invasion by Crohn's Disease-Associated Adherent-InvasiveFrontiers in microbiology · 2018Article
- Surface-Associated Lipoproteins Link Enterococcus faecalis Virulence to Colitogenic Activity in IL-10-Deficient Mice Independent of Their Expression Levels.PLoS pathogens · 2015Article
- Professor Arlette Darfeuille-Michaud: the discovery of adherent-invasive Escherichia coli.Journal of Crohn's & colitis · 2015Article
- Analysis of the σE regulon in Crohn's disease-associated Escherichia coli revealed involvement of the waaWVL operon in biofilm formation.Journal of bacteriology · 2015Article
- Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay.Antimicrobial agents and chemotherapy · 2015Article
- Infectious etiopathogenesis of Crohn's disease.World journal of gastroenterology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ileal lesions of patients with Crohn's disease are colonized by adherent-invasive Escherichia coli (AIEC) bacteria that are able to adhere to and invade intestinal epithelial cells (IEC), to replicate within macrophages, and to form biofilm. Clinical observations showed that bacterial biofilms were associated with the mucosa of inflammatory bowel disease patients. In the present study, we analyzed the relationship between AIEC colonization of the gut and the formation of biofilm, focusing on the involvement of the σ(E) pathway in the AIEC-IEC interaction. We observed that σ(E) pathway inhibition in AIEC reference strain LF82 led to an impaired ability to adhere to and invade IEC but also induced a large decrease in the abilities to colonize the intestinal mucosa and form biofilm. This indicates that targeting of the σ(E) pathway could be a very potent therapeutic strategy by which to interfere with the ability of AIEC to form biofilm on the gut mucosa of Crohn's disease patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.