ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Separating in vivo mechanical stimuli for postpneumonectomy compensation: physiological assessment.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Paxillin in mechanosensitive spatial control of lung endothelial cell regeneration.NPJ Regenerative medicine · 2026Article
- Lung function measurements in preclinical research: What has been done and where is it headed?Frontiers in physiology · 2023Review
- Continuous purification and culture of rat type 1 and type 2 alveolar epithelial cells by magnetic cell sorting.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2022Article
- Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Lung organoids, useful tools for investigating epithelial repair after lung injury.Stem cell research & therapy · 2021Review
- Inhalational delivery of induced pluripotent stem cell secretome improves postpneumonectomy lung structure and function.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Lung microstructure in adolescent idiopathic scoliosis before and after posterior spinal fusion.PloS one · 2020Article
- Erythropoietin inhalation enhances adult canine alveolar-capillary formation following pneumonectomy.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration.Frontiers in bioengineering and biotechnology · 2019Review
- Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?The Journal of pediatrics · 2017Review
- Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy.Cell stem cell · 2017Article
- Comparative analysis of the mechanical signals in lung development and compensatory growth.Cell and tissue research · 2017Review
- Perfusion-related stimuli for compensatory lung growth following pneumonectomy.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Lung Structure and the Intrinsic Challenges of Gas Exchange.Comprehensive Physiology · 2016Review
- Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches.International journal of molecular sciences · 2016Review
- Localization and stretch-dependence of lung elastase activity in development and compensatory growth.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Mouse pneumonectomy model of compensatory lung growth.Journal of visualized experiments : JoVE · 2014Article
- Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.Cell stem cell · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Following right pneumonectomy (PNX), the remaining lung expands and its perfusion doubles. Tissue and microvascular mechanical stresses are putative stimuli for initiating compensatory lung growth and remodeling, but their relative contributions to overall compensation remain uncertain. To temporally isolate the stimuli related to post-PNX lung expansion (parenchyma deformation) from those related to the sustained increase in perfusion (microvascular distention and shear), we replaced the right lung of adult dogs with a custom-shaped inflated prosthesis. Following stabilization of perfusion and wound healing 4 mo later, the prosthesis was either acutely deflated (DEF group) or kept inflated (INF group). Physiological studies were performed pre-PNX, 4 mo post-PNX (inflated prosthesis, INF1), and again 4 mo postdeflation (DEF) compared with controls with simultaneous INF prosthesis (INF2). Perfusion to the remaining lung increased ~76-113% post-PNX (INF1 and INF2) and did not change postdeflation. Post-PNX (INF prosthesis) end-expiratory lung volume (EELV) and lung and membrane diffusing capacities (DL(CO) and DM(CO)) at a given perfusion were 25-40% below pre-PNX baseline. In the INF group EELV, DL(CO) and DM(CO) remained stable or declined slightly with time. In contrast, all of these parameters increased significantly after deflation and were 157%, 26%, and 47%, respectively, above the corresponding control values (INF2). Following delayed deflation, lung expansion accounted for 44%-48% of total post-PNX compensatory increase in exercise DL(CO) and peak O(2) uptake; the remainder fraction is likely attributable to the increase in perfusion. Results suggest that expansion-related parenchyma mechanical stress and perfusion-related microvascular stress contribute in equal proportions to post-PNX alveolar growth and remodeling.
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Registered trials
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