Evidence map›Paper›PMID 23104669›Full record

ArticleSocial psychiatry and psychiatric epidemiology2013

Cancer mortality in patients with psychiatric diagnoses: a higher hazard of cancer death does not lead to a higher cumulative risk of dying from cancer.

Ng Chong Guan, Fabian Termorshuizen, Wijnand Laan, Hugo M Smeets, Nor Zuraida Zainal, René S Kahn, Niek J De Wit, Marco P M Boks

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Article in Social psychiatry and psychiatric epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  12. Why are somatic diseases in bipolar disorder insufficiently treated?International journal of bipolar disorders · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ng Chong GuanFaculty of Medicine, Department of Psychological Medicine, University of Malaya, Malaya, Malaysia.
Fabian Termorshuizen
Wijnand Laan
Hugo M Smeets
Nor Zuraida Zainal
René S Kahn
Niek J De Wit
Marco P M Boks

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBoth increased as well as decreased cancer mortality among psychiatric patients has been reported, but competing death causes were not included in the analyses. This study aims to investigate whether observed cancer mortality in patients with psychiatric disorders might be biased by competing death causes.

methodIn this retrospective cohort study on data from the Psychiatric Case Register Middle Netherlands linked to the death register of Statistics Netherlands, the risk of cancer death among patients with schizophrenia (N = 4,590), bipolar disorder (N = 2,077), depression (N = 15,130) and their matched controls (N = 87,405) was analyzed using a competing risk model.

resultsCompared to controls, higher hazards of cancer death were found in patients with schizophrenia (HR = 1.61, 95 % CI 1.26-2.06), bipolar disorder (HR = 1.20, 95 % CI 0.81-1.79) and depression (HR = 1.26, 95 % CI 1.10-1.44). However, the HRs of death due to suicide and other death causes were more elevated. Consequently, among those who died, the 12-year cumulative risk of cancer death was significantly lower.

conclusionsOur analysis shows that, compared to the general population, psychiatric patients are at higher risk of dying from cancer, provided that they survive the much more elevated risks of suicide and other death causes.

Indexed as

AdultBipolar DisorderCase-Control StudiesDepressive DisorderFemaleHumansMaleMiddle AgedNeoplasmsNetherlandsOdds RatioProportional Hazards ModelsRegistriesRetrospective StudiesRisk FactorsSchizophrenia

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.