Evidence map›Paper›PMID 23104606›Full record

ArticleThe American journal of sports medicine2012

Do cartilage repair procedures prevent degenerative meniscus changes?: longitudinal t1ρ and morphological evaluation with 3.0-T MRI.

Pia M Jungmann, Xiaojuan Li, Lorenzo Nardo, Karupppasamy Subburaj, Wilson Lin, C Benjamin Ma, Sharmila Majumdar, Thomas M Link

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of sports medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Medial Osteochondral Defect Drives Matrix and Cell Pathology in Compartment-Matched Meniscus.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  2. Synovial mesenchymal stem cells promote the meniscus repair in a novel pig meniscus injury model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
    Article
  3. Article
  4. Observational
  5. T₁ρ MRI of human musculoskeletal system.Journal of magnetic resonance imaging : JMRI · 2015
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Pia M JungmannMusculoskeletal and Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, University of California–San Francisco, San Francisco, California, USA. pia.jungmann@tum.de
Xiaojuan Li
Lorenzo Nardo
Karupppasamy Subburaj
Wilson Lin
C Benjamin Ma
Sharmila Majumdar
Thomas M Link
University of California, San Francisco · US

Funding

MRI TO STUDY CARTILAGE/BONE INTERACTIONSR01AR046905 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 1999 to 2015
$6.3M
Translation of Quantitative Imaging in OsteoarthritisP50AR060752 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2011 to 2015
$6.2M
In Vivo Early Detection of Cartilage Degeneration Using High Field MRIK25AR053633 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, XIAOJUAN · 2006 to 2010
$708k
T2 Relaxation Time of Knee Cartilage in the OAI Incidence SubcohortU01AR059507 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LINK, THOMAS M · 2010 to 2012
$499k
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
–
CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
–
DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
–
NIAMS NIH HHS K25 AR053633NIAMS NIH HHS N01-AR-2-2258NIAMS NIH HHS N01- AR-2-2259NIAMS NIH HHS N01-AR-2-2260NIAMS NIH HHS N01-AR-2-2261NIAMS NIH HHS N01-AR-2-2262NIAMS NIH HHS P50 AR060752NIAMS NIH HHS R01 AR046905NIAMS NIH HHS R01 AR46905NIAMS NIH HHS U01 AR059507NIAMS NIH HHS UO1 AR059507
6 · The paper itself

Abstract

backgroundCartilage repair (CR) procedures are widely accepted for treatment of isolated cartilage defects in the knee joint. However, it is not well known whether these procedures prevent degenerative joint disease. HYPOTHESIS: Cartilage repair procedures prevent accelerated qualitative and quantitative progression of meniscus degeneration in individuals with focal cartilage defects. STUDY

designCohort study; Level of evidence, 2.

methodsNinety-four subjects were studied. Cartilage repair procedures were performed on 34 patients (osteochondral transplantation, n = 16; microfracture, n = 18); 34 controls were matched. An additional 13 patients received CR and anterior cruciate ligament (ACL) reconstruction (CR&ACL), and 13 patients received only ACL reconstruction. Magnetic resonance imaging at 3.0-tesla with T(1ρ) mapping and sagittal fat-saturated intermediate-weighted fast spin echo (FSE) sequences was performed to quantitatively and qualitatively analyze menisci (Whole-Organ Magnetic Resonance Imaging Score [WORMS] assessment). Patients in the CR and CR&ACL groups were examined 4 months (n = 34; n = 13), 1 year (n = 21; n = 8), and 2 years (n = 9; n = 5) after CR. Control subjects were scanned at baseline and after 1 and 2 years, ACL patients after 1 and 2 years.

resultsAt baseline, global meniscus T(1ρ) values (mean ± SEM) were higher in individuals with CR (14.2 ± 0.5 ms; P = .004) and in individuals with CR&ACL (17.1 ± 0.9 ms; P < .001) when compared with controls (12.8 ± 0.6 ms). After 2 years, there was a statistical difference between T(1ρ) at the overlying meniscus above cartilage defects (16.4 ± 1.0 ms) and T(1ρ) of the subgroup of control knees without cartilage defects (12.1 ± 0.8 ms; P < .001) and a statistical trend to the CR group (13.3 ± 1.0 ms; P = .09). At baseline, 35% of subjects with CR showed morphological meniscus tears at the overlying meniscus; 10% of CR subjects showed an increase in the WORMS meniscus score within the first year, and none progressed in the second year. Control subjects with (without) cartilage defects showed meniscus tears in 30% (5%) at baseline; 38% (19%) increased within the first year, and 15% (10%) within the second year.

conclusionThis study demonstrated more severe meniscus degeneration after CR surgery compared with controls. However, progression of T(1ρ) values was not observed from 1 to 2 years after surgery. These results suggest that CR may prevent degenerative meniscus changes.

Indexed as

Arthroplasty, SubchondralAdultAnterior Cruciate Ligament ReconstructionBone MarrowFemaleFollow-Up StudiesHumansKnee InjuriesMagnetic Resonance ImagingMaleMenisci, TibialMiddle AgedYoung Adult

Identifiers

PMID23104606
PMCPMC4074395
OpenAlexW2027824739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.