ReviewBiochimica et biophysica acta2013
Pivots of pluripotency: the roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells.
Review in Biochimica et biophysica acta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Profiling mitochondria-polyribosome lncRNAs associated with pluripotency.Scientific data · 2023Article
- Circular RNAs in stem cells: from basic research to clinical implications.Bioscience reports · 2022Review
- Review
- Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.Experimental cell research · 2019Article
- Metabolomics Analysis of Mesenchymal Stem Cells.International journal of molecular and cellular medicine · 2019Review
- JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process.BMC genomics · 2018Article
- Vigor of survival determinism: subtle evolutionary gradualism interspersed with robust phylogenetic leaping.Theory in biosciences = Theorie in den Biowissenschaften · 2017Article
- Long Non Coding RNA Expression Intersecting Cancer and Spermatogenesis: A Systematic ReviewAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Non-coding RNAs are promising targets for stem cell-based cancer therapy.Non-coding RNA research · 2017Review
- A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness.Nucleic acids research · 2016Article
- Nothing in Evolution Makes Sense Except in the Light of Genomics: Read-Write Genome Evolution as an Active Biological Process.Biology · 2016Review
- Transcriptome profile of the early stages of breast cancer tumoral spheroids.Scientific reports · 2016Article
- Reprogramming barriers and enhancers: strategies to enhance the efficiency and kinetics of induced pluripotency.Cell regeneration (London, England) · 2015Article
- Comparison of long non‑coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma.Molecular medicine reports · 2014Article
- The functional role of long non-coding RNAs and epigenetics.Biological procedures online · 2014Review
- Transient acid treatment cannot induce neonatal somatic cells to become pluripotent stem cells.F1000Research · 2014Article
- Minireview: Long noncoding RNAs: new "links" between gene expression and cellular outcomes in endocrinology.Molecular endocrinology (Baltimore, Md.) · 2013Review
- Long noncoding RNAs: new players in the molecular mechanism for maintenance and differentiation of pluripotent stem cells.Stem cells and development · 2013Review
- RNA-binding protein Rbm47 binds to Nanog in mouse embryonic stem cells.Molecular biology reports · 2013Article
- Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis.The Journal of clinical investigation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInduced pluripotent stem cells (iPSC) derived from reprogrammed patient somatic cells possess enormous therapeutic potential. However, unlocking the full capabilities of iPSC will require an improved understanding of the molecular mechanisms which govern the induction and maintenance of pluripotency, as well as directed differentiation to clinically relevant lineages. Induced pluripotency of a differentiated cell is mediated by sequential cascades of genetic and epigenetic reprogramming of somatic histone and DNA CpG methylation marks. These genome-wide changes are mediated by a coordinated activity of transcription factors and epigenetic modifying enzymes. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are now recognized as an important third class of regulators of the pluripotent state. SCOPE OF REVIEW: This review surveys the currently known roles and mechanisms of ncRNAs in regulating the embryonic and induced pluripotent states. MAJOR
conclusionsThrough a variety of mechanisms, ncRNAs regulate constellations of key pluripotency genes and epigenetic regulators, and thus critically determine induction and maintenance of the pluripotent state. GENERAL SIGNIFICANCE: A further understanding of the roles of ncRNAs in regulating pluripotency may help assess the quality of human iPSC reprogramming. Additionally, ncRNA biology may help decipher potential transcriptional and epigenetic commonalities between the self renewal processes that govern both ESC and tumor initiating cancer stem cells (CSC). This article is part of a Special Issue entitled Biochemistry of Stem Cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.