Trial reportHernia : the journal of hernias and abdominal wall surgery2013
The effect of preemptive analgesia with bupivacaine on postoperative pain of inguinal hernia repair under spinal anesthesia: a randomized clinical trial.
Trial report in Hernia : the journal of hernias and abdominal wall surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Comparison of liposomal bupivacaine erector spinae plane block versus wound infiltration for postoperative analgesia and quality of recovery in lumbar fusion surgery: a randomized controlled trial.European journal of medical research · 2025Trial
- Pain during and after-hernioplasty in raquidian or locorregional anesthesia by locking peripheral nerves.Hernia : the journal of hernias and abdominal wall surgery · 2019Article
- Impact of volume expansion on the efficacy and pharmacokinetics of liposome bupivacaine.Local and regional anesthesia · 2015Review
- Comparison of the analgesic effect of intra-articular and extra-articular injection of morphine and ketamine compound in arthrotomy lower limb surgery under spinal anesthesia.Pakistan journal of medical sciences · 2014Article
- Comparison of low and standard pressure gas injection at abdominal cavity on postoperative nausea and vomiting in laparoscopic cholecystectomy.Pakistan journal of medical sciences · 2014Article
- The effect of single-dose administration of dexamethasone on postoperative pain in patients undergoing laparoscopic cholecystectomy.Anesthesiology and pain medicine · 2014Article
- The effect of low-level laser on postoperative pain after tibial fracture surgery: a double-blind controlled randomized clinical trial.Anesthesiology and pain medicine · 2014Article
- Analgesic effect of low dose subcutaneous ketamine administration before and after cesarean section.Iranian Red Crescent medical journal · 2014Article
- The comparison of spinal anesthesia with general anesthesia on the postoperative pain scores and analgesic requirements after elective lower abdominal surgery: A randomized, double-blinded study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Morphine after tubal ligation with bupivacaine: dosage versus body weight.JSLS : Journal of the Society of Laparoendoscopic SurgeonsArticle
- Effects of preincisional analgesia with surgical site infiltration of ketamine or levobupivacaine in patients undergoing abdominal hysterectomy under general anesthesia; A randomized double blind study.Saudi journal of anaesthesiaArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn the absence of any study on the use of bupivacaine as a long acting local anesthetic for the purpose of inducing preemptive analgesia in patients undergoing inguinal hernia repair under spinal anesthesia, this study was conducted to provide some evidence for possible benefits of such practice.
methodsIn this randomized clinical trial, local infiltration of bupivacaine in patients undergoing inguinal hernia repair under spinal anesthesia was compared with placebo. The patients were randomly divided to two groups of 30 including the case group who received 10 cc of 0.5 % bupivacaine and the control group who received 10 cc of normal saline in the operation site before surgical incision. At the end of spinal block effect, patients were followed for symptoms of pain intensity according to numerical rating scale method, nausea, vomiting and opioid use for 24 h past the operation.
resultsThe pain scores, nausea, vomiting and postoperative opioid use were 69.6, 76.5, 83.2 and 80 % respectively lower in first 24 h among the case group (P < 0.001, P = 0.005, P = 0.001 and P < 0.001). The number of patients with at least one analgesic request in first 24 h after operation was 64.2 % lower in case group, while time of first analgesic request was 67 % longer in treatment group (P < 0.001 and P < 0.001).
conclusionThe pre-operative local infiltration of bupivacaine reduces pain, nausea, vomiting and opioid use in the first 24 h after inguinal hernia surgery under spinal anesthesia. Therefore, further evaluation of the efficacy of this technique as a modality of preemptive analgesia is suggested.
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