ArticleBreast cancer research and treatment2012
Collaborative modeling of the impact of obesity on race-specific breast cancer incidence and mortality.
Article in Breast cancer research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Simulation models for socioeconomic inequalities in health: a systematic review.International journal of environmental research and public health · 2013Pooled it
- Population simulation modeling of disparities in US breast cancer mortality.Journal of the National Cancer Institute. Monographs · 2023Article
- A health equity framework to support the next generation of cancer population simulation models.Journal of the National Cancer Institute. Monographs · 2023Article
- Opportunities, challenges, and future directions for simulation modeling the effects of structural racism on cancer mortality in the United States: a scoping review.Journal of the National Cancer Institute. Monographs · 2023Article
- Stage distinctive communication networks of the online breast cancer community.Scientific reports · 2023Article
- Identifying Equitable Screening Mammography Strategies for Black Women in the United States Using Simulation Modeling.Annals of internal medicine · 2021Article
- Reflecting on 20 years of breast cancer modeling in CISNET: Recommendations for future cancer systems modeling efforts.PLoS computational biology · 2021Review
- Literature review of data-based models for identification of factors associated with racial disparities in breast cancer mortality.Health systems (Basingstoke, England) · 2019Review
- Structure, Function, and Applications of the Georgetown-Einstein (GE) Breast Cancer Simulation Model.Medical decision making : an international journal of the Society for Medical Decision Making · 2018Article
- Common Model Inputs Used in CISNET Collaborative Breast Cancer Modeling.Medical decision making : an international journal of the Society for Medical Decision Making · 2018Article
- Comparing CISNET Breast Cancer Models Using the Maximum Clinical Incidence Reduction Methodology.Medical decision making : an international journal of the Society for Medical Decision Making · 2018Article
- Using Collaborative Simulation Modeling to Develop a Web-Based Tool to Support Policy-Level Decision Making About Breast Cancer Screening Initiation Age.MDM policy & practice · 2017Article
- Collaborative Modeling of the Benefits and Harms Associated With Different U.S. Breast Cancer Screening Strategies.Annals of internal medicine · 2016Article
- The contribution of mammography screening to breast cancer incidence trends in the United States: an updated age-period-cohort model.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Estimating population attributable fractions to quantify the health burden of obesity.Annals of epidemiology · 2015Review
- Personalizing age of cancer screening cessation based on comorbid conditions: model estimates of harms and benefits.Annals of internal medicine · 2014Article
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9 authors.
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Abstract
Obesity affects multiple points along the breast cancer control continuum from prevention to screening and treatment, often in opposing directions. Obesity is also more prevalent in Blacks than Whites at most ages so it might contribute to observed racial disparities in mortality. We use two established simulation models from the Cancer Intervention and Surveillance Modeling Network (CISNET) to evaluate the impact of obesity on race-specific breast cancer outcomes. The models use common national data to inform parameters for the multiple US birth cohorts of Black and White women, including age- and race-specific incidence, competing mortality, mammography characteristics, and treatment effectiveness. Parameters are modified by obesity (BMI of ≥ 30 kg/m(2)) in conjunction with its age-, race-, cohort- and time-period-specific prevalence. We measure age-standardized breast cancer incidence and mortality and cases and deaths attributable to obesity. Obesity is more prevalent among Blacks than Whites until age 74; after age 74 it is more prevalent in Whites. The models estimate that the fraction of the US breast cancer cases attributable to obesity is 3.9-4.5 % (range across models) for Whites and 2.5-3.6 % for Blacks. Given the protective effects of obesity on risk among women <50 years, elimination of obesity in this age group could increase cases for both the races, but decrease cases for women ≥ 50 years. Overall, obesity accounts for 4.4-9.2 % and 3.1-8.4 % of the total number of breast cancer deaths in Whites and Blacks, respectively, across models. However, variations in obesity prevalence have no net effect on race disparities in breast cancer mortality because of the opposing effects of age on risk and patterns of age- and race-specific prevalence. Despite its modest impact on breast cancer control and race disparities, obesity remains one of the few known modifiable risks for cancer and other diseases, underlining its relevance as a public health target.
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