ArticleBiomedical microdevices2013
Proliferation and migration of tumor cells in tapered channels.
Article in Biomedical microdevices, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- The emerging role of aptamers in targeted cancer immunotherapy.Molecular therapy. Oncology · 2026Review
- A SERS/fluorescence dual-mode immuno-nanoprobe for investigating two anti-diabetic drugs on EGFR expressions.Mikrochimica acta · 2023Article
- Quantitative cell imaging approaches to metastatic state profiling.Frontiers in cell and developmental biology · 2022Review
- A comparative assessment ofRSC advances · 2021Article
- Aptamer-Based In Vivo Therapeutic Targeting of Glioblastoma.Molecules (Basel, Switzerland) · 2020Review
- The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature.Cancers · 2020Review
- The Concept of Making On-Chip Thermal Cycler for RT-PCR Using Conjugate Heat Transfer in Diverging Microchannel.Transactions of the Indian National Academy of Engineering : an international journal of engineering and technology · 2020Article
- Using an RNA aptamer probe for super-resolution imaging of native EGFR.Nanoscale advances · 2019Article
- Post-gadolinium 3-dimensional spatial, surface, and structural characteristics of glioblastomas differentiate pseudoprogression from true tumor progression.Journal of neuro-oncology · 2018Article
- Aptamer Therapeutics in Cancer: Current and Future.Cancers · 2018Review
- GdSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2017Article
- Circulating tumor cell detection: A direct comparison between negative and unbiased enrichment in lung cancer.Oncology letters · 2017Article
- Brain Tumor Genetic Modification Yields Increased Resistance to Paclitaxel in Physical Confinement.Scientific reports · 2016Article
- Aptamers: A promising chemical antibody for cancer therapy.Oncotarget · 2016Review
- A simple and novel way of maintaining constant wall temperature in microdevices.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Tumor cells depict two deviant tendencies; over-proliferation and vigorous migration. A tapered channel device is designed and fabricated for in vitro studies. We report inhibited proliferation and migration of human glioblastoma (hGBM) cells when exposed to an aptamer that is known to bind epidermal growth factor receptors (EGFR). The device is integrated with controlled ambient and microscope for providing real-time and quantitative characterization of the tumor cell behavior. The results show that hGBM cells loose proliferation and motility when exposed to the anti-EGFR aptamer. The aptamer directly inhibits and blocks EGF-induced EGFR phosphorylation. This also reduces the ability of cells to remodel their internal structure for invasion through narrow constrictions. This provides a framework for possible studies on efficacy of other inhibiting molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.