ReviewMolecular bioSystems2013
Understanding protein aggregation from the view of monomer dynamics.
Review in Molecular bioSystems, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Inhibition of Polyglutamine Misfolding with D-Enantiomeric Peptides Identified by Mirror Image Phage Display Selection.Biomolecules · 2022Article
- Characterization of Amyloidogenic Peptide Aggregability in Helical Subspace.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Rational Development of Stable PYYPharmaceutical research · 2021Article
- Thermodynamics and kinetics of the amyloid-β peptide revealed by Markov state models based on MD data in agreement with experiment.Chemical science · 2021Article
- Friction-Limited Folding of Disulfide-Reduced Monomeric SOD1.Biophysical journal · 2020Article
- Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.Neurobiology of disease · 2017Article
- Equilibrium Ensembles for Insulin Folding from Bias-Exchange Metadynamics.Biophysical journal · 2017Article
- Prion protein dynamics before aggregation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Monomer Dynamics of Alzheimer Peptides and Kinetic Control of Early Aggregation in Alzheimer's Disease.Chemphyschem : a European journal of chemical physics and physical chemistry · 2016Article
- Intramolecular diffusion controls aggregation of the PAPf39 peptide.Biophysical chemistry · 2016Article
- Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores.The Yale journal of biology and medicine · 2016Review
- Effects of Mutations on the Reconfiguration Rate of α-Synuclein.The journal of physical chemistry. B · 2015Article
- Direct Detection of α-Synuclein Dimerization Dynamics: Single-Molecule Fluorescence Analysis.Biophysical journal · 2015Article
- A coarse-grained model for polyglutamine aggregation modulated by amphipathic flanking sequences.Biophysical journal · 2014Article
- Structure and mechanism of action of tau aggregation inhibitors.Current Alzheimer research · 2014Review
- α-Synuclein misfolding assessed with single molecule AFM force spectroscopy: effect of pathogenic mutations.Biochemistry · 2013Article
- A quantitative measure for protein conformational heterogeneity.The Journal of chemical physics · 2013Article
Corrections and comments
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Authors and funding
1 author.
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Abstract
Much work in recent years has been devoted to understanding the complex process of protein aggregation. This review looks at the earliest stages of aggregation, long before the formation of fibrils that are the hallmark of many aggregation-based diseases, and proposes that the first steps are controlled by the reconfiguration dynamics of the monomer. When reconfiguration is much faster or much slower than bimolecular diffusion, then aggregation is slow, but when they are similar, aggregation is fast. The experimental evidence for this model is reviewed and the prospects for small molecule aggregation inhibitors to prevent disease are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.