ArticleAmerican journal of respiratory cell and molecular biology2013
Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.
Article in American journal of respiratory cell and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Three-dimensional modeling of sensory nerve architecture and eosinophil and mast cell interactions in eosinophilic gastrointestinal disease.Journal of leukocyte biology · 2026Article
- The Expanding Role of ILC2s in Allergic Airways Disease.Allergy · 2026Review
- Touching a Nerve: Neuroimmune Interactions in Asthma.Immunological reviews · 2025Review
- Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now?Biomedicines · 2025Article
- Review
- Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Identification of lung innervating sensory neurons and their target specificity.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Mini review: Neural mechanisms underlying airway hyperresponsiveness.Neuroscience letters · 2021Review
- Branching Out in Chronic Cough: Evidence for Increased Airway Nerve Density.American journal of respiratory and critical care medicine · 2021Article
- Airway Sensory Nerve Density Is Increased in Chronic Cough.American journal of respiratory and critical care medicine · 2021Article
- Airway Sensory Nerve Plasticity in Asthma and Chronic Cough.Frontiers in physiology · 2021Review
- Eosinophils increase airway sensory nerve density in mice and in human asthma.Science translational medicine · 2018Article
- Morphologic Characterization of Nerves in Whole-Mount Airway Biopsies.American journal of respiratory and critical care medicine · 2015Article
- Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice.The Journal of allergy and clinical immunology · 2015Article
- Tissue optical clearing, three-dimensional imaging, and computer morphometry in whole mouse lungs and human airways.American journal of respiratory cell and molecular biology · 2014Article
- Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry.eNeuroArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The quantitative histological analysis of airway innervation using tissue sections is challenging because of the sparse and patchy distribution of nerves. Here we demonstrate a method using a computational approach to measure airway nerve architecture that will allow for more complete nerve quantification and the measurement of structural peripheral neuroplasticity in lung development and disease. We demonstrate how our computer analysis outperforms manual scoring in quantifying three-dimensional nerve branchpoints and lengths. In murine lungs, we detected airway epithelial nerves that have not been previously identified because of their patchy distribution, and we quantified their three-dimensional morphology using our computer mapping approach. Furthermore, we show the utility of this approach in bronchoscopic forceps biopsies of human airways, as well as the esophagus, colon, and skin.
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