ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)
Design and in vitro assessment of an improved, low-resistance compliant thoracic artificial lung.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Evolution of extracorporeal membrane oxygenation: historical milestones and advanced developments.The journal of extra-corporeal technology · 2025Review
- Bioengineering Progress in Lung Assist Devices.Bioengineering (Basel, Switzerland) · 2021Review
- First in vivo assessment of RAS-Q technology as lung support device for pulmonary hypertension.The International journal of artificial organs · 2021Article
- The Roles of Membrane Technology in Artificial Organs: Current Challenges and Perspectives.Membranes · 2021Review
- Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- In Vivo 5 Day Animal Studies of a Compact, Wearable Pumping Artificial Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2019Article
- Early in vivo experience with the pediatric continuous-flow total artificial heart.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018Article
- In vitro and in vivo evaluation of a novel integrated wearable artificial lung.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2017Article
- Use of a low-resistance compliant thoracic artificial lung in the pulmonary artery to pulmonary artery configuration.The Journal of thoracic and cardiovascular surgery · 2013Article
- Fourteen Day In Vivo Testing of a Compliant Thoracic Artificial Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
- Fiber Bundle Design for an Integrated Wearable Artificial Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
- Darcy Permeability of Hollow Fiber Membrane Bundles Made from Membrana Polymethylpentene Fibers Used in Respiratory Assist Devices.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Current thoracic artificial lungs (TALs) have blood flow impedances greater than the natural lungs, which can result in abnormal pulmonary hemodynamics. This study investigated the impedance and gas transfer performance of a compliant TAL (cTAL). Fluid-structure interaction analysis was performed using ADINA (ADINA R&D Inc., Watertown, MA) to examine the effect of the inlet and outlet expansion angle, θ, on device impedance and blood flow patterns. Based on the results, the θ = 45° model was chosen for prototyping and in vitro testing. Glycerol was pumped through this cTAL at 2, 4, and 6 L/min at 80 and 100 beats/min, and the zeroth and first harmonic impedance moduli, Z(0) and Z(1), were calculated. Gas transfer testing was conducted at blood flow rates of 3, 5, and 7 L/min. Fluid-structure interaction results indicated that the 45° model had an ideal combination of low impedance and even blood flow patterns and was thus chosen for prototyping. In vitro, Z(0) = 0.53 ± 0.06 mm Hg/(L/min) and Z(1) = 0.86 ± 0.08 mm Hg/(L/min) at 4 L/min and 100 beats/min. Outlet PO(2) and SO(2) values were above 200 mm Hg and 99.5%, respectively, at each flow rate. Thus, the cTAL had lower impedance than hard shell TALs and excellent gas transfer.
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