ArticleNeuropharmacology2013
Adolescent male rats are less sensitive than adults to the anxiogenic and serotonin-releasing effects of fenfluramine.
Article in Neuropharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Impact of altered environment and early postnatal methamphetamine exposure on serotonin levels in the rat hippocampus during adolescence.Laboratory animal research · 2024Article
- Activation of renal vascular smooth muscle TRPV4 channels by 5-hydroxytryptamine impairs kidney function in neonatal pigs.Microvascular research · 2023Article
- Disturbance of neurotransmitter metabolism in drug-naïve, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts.European archives of psychiatry and clinical neuroscience · 2022Article
- Withdrawal from Brief Repeated Alcohol Treatment in Adolescent and Adult Male and Female Rats.Alcoholism, clinical and experimental research · 2019Article
- Early onset cigarette smokers exhibit greater P300 reactivity to smoking-related stimuli and report greater craving.Brain research · 2018Article
- Effects of quercetin on predator stress-related hematological and behavioral alterations in pregnant rats and their offspring.Journal of biosciences · 2016Article
- Neurochemical correlates of accumbal dopamine D2 and amygdaloid 5-HT 1B receptor densities on observational learning of aggression.Cognitive, affective & behavioral neuroscience · 2015Article
- Laboratory environment and bio-medical experience: the impact of administration technique on the quality of immune-behavior data results in stress experience.BioImpacts : BI · 2015Article
- Axonal control of the adult neural stem cell niche.Cell stem cell · 2014Article
- Viral over-expression of D1 dopamine receptors in the prefrontal cortex increase high-risk behaviors in adults: comparison with adolescents.Psychopharmacology · 2014Article
- Use of the light/dark test for anxiety in adult and adolescent male rats.Behavioural brain research · 2013Article
- Lower anxiogenic effects of serotonin agonists are associated with lower activation of amygdala and lateral orbital cortex in adolescent male rats.Neuropharmacology · 2013Article
- Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
Risk taking behavior increases during adolescence, which is also a critical period for the onset of drug abuse. The central serotonergic system matures during the adolescent period, and its immaturity during early adolescence may contribute to adolescent risk taking, as deficits in central serotonergic function have been associated with impulsivity, aggression, and risk taking. We investigated serotonergic modulation of behavior and presynaptic serotonergic function in adult (67-74 days old) and adolescent (28-34 days old) male rats. Fenfluramine (2 mg/kg, i.p.) produced greater anxiogenic effects in adult rats in both the light/dark and elevated plus maze tests for anxiety-like behavior, and stimulated greater increases in extracellular serotonin in the adult medial prefrontal cortex (mPFC) (1, 2.5, and 10 mg/kg, i.p.). Local infusion of 100 mM potassium chloride into the mPFC also stimulated greater serotonin efflux in adult rats. Adult rats had higher tissue serotonin content than adolescents in the prefrontal cortex, amygdala, and hippocampus, but the rate of serotonin synthesis was similar between age groups. Serotonin transporter (SERT) immunoreactivity and SERT radioligand binding were comparable between age groups in all three brain regions. These data suggest that lower tissue serotonin stores in adolescents limit fenfluramine-stimulated serotonin release and so contribute to the lesser anxiogenic effects of fenfluramine.
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