ArticleJournal of the American College of Cardiology2012
Temporal trends and geographic variation of lower-extremity amputation in patients with peripheral artery disease: results from U.S. Medicare 2000-2008.
Article in Journal of the American College of Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 185 citations in OpenAlex.
- Diversity in randomized clinical trials for peripheral artery disease: a systematic review.International journal for equity in health · 2024Pooled it
- Determinants of Potentially Inappropriate Medication Use in Long-Term and Acute Care Settings: A Systematic Review.Journal of the American Medical Directors Association · 2017Pooled it
- New Method of Percutaneous Revascularization Treating Severe and Hard-to-Treat Chronic Limb-Threatening.Pakistan journal of medical sciences · 2026Article
- Socioeconomic Inequities in Abdominal Aortic Aneurysm Screening Uptake Among Women: A Narrative Review.Cureus · 2025Review
- The Effects of Virtual Reality Interventions on Motor Function Rehabilitation in Lower-Limb Amputees: A Systematic Review and Metanalysis.Bioengineering (Basel, Switzerland) · 2025Review
- Perioperative Events Following Open Versus Endovascular Revascularization for Chronic Limb-Threatening Ischemia: An NSQIP Analysis.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Advancing Health Equity in the Cardiovascular Device Life Cycle.Circulation. Cardiovascular quality and outcomes · 2025Review
- Forecasting the Global Burden of Peripheral Artery Disease from 2021 to 2050: A Population-Based Study.Research (Washington, D.C.) · 2025Article
- Racial and Socioeconomic Health Disparities in Peripheral Artery Disease.Journal of the American Heart Association · 2024Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Treatment Variability Among Patients Hospitalized for Chronic Limb-Threatening Ischemia: An Analysis of the 2016 to 2018 US National Inpatient Sample.Journal of the American Heart Association · 2024Article
- Vascular surgeons are positioned to fight healthcare disparities.Journal of vascular surgery. Venous and lymphatic disorders · 2024Review
- Trends in peripheral artery disease and critical limb ischemia hospitalizations among cocaine and methamphetamine users in the United States: a nationwide study.Frontiers in cardiovascular medicine · 2024Article
- Diversity in clinical trial inclusion for peripheral artery disease lower extremity endovascular interventions: a systematic review protocol.Journal of comparative effectiveness research · 2023Article
- Trends of Concomitant Diabetes and Peripheral Artery Disease and Lower Extremity Amputation in US Medicare Patients, 2007 to 2019.Circulation. Cardiovascular quality and outcomes · 2023Article
- Non-esterified fatty acids and risk of peripheral artery disease in older adults: The cardiovascular health study.Atherosclerosis · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Salami-Tactics: when is it time for a major cut after multiple minor amputations?Archives of orthopaedic and trauma surgery · 2023Article
- Black men's awareness of peripheral artery disease and acceptability of screening in barbershops: a qualitative analysis.BMC public health · 2023Article
- Epidemiology and Outcome of Nontraumatic Lower Limb Amputations.Medical journal of the Islamic Republic of Iran · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThis study sought to characterize temporal trends, patient-specific factors, and geographic variation associated with amputation in patients with lower-extremity peripheral artery disease (LE PAD) during the study period.
backgroundAmputation represents the end-stage failure for those with LE PAD, and little is known about the rates and geographic variation in the use of LE amputation.
methodsBy using data from the Centers for Medicare & Medicaid Services (CMS) from January 1, 2000, to December 31, 2008, we examined national patterns of LE amputation among patients age 65 years or more with PAD. Multivariable logistic regression was used to adjust regional results for other patient demographic and clinical factors.
resultsAmong 2,730,742 older patients with identified PAD, the overall rate of LE amputation decreased from 7,258 per 100,000 patients with PAD to 5,790 per 100,000 (p < 0.001 for trend). Male sex, black race, diabetes mellitus, and renal disease were all independent predictors of LE amputation. The adjusted odds ratio of LE amputation per year between 2000 and 2008 was 0.95 (95% CI: 0.95-0.95, p < 0.001).
conclusionsFrom 2000 to 2008, LE amputation rates decreased significantly among patients with PAD. However, there remains significant patient and geographic variation in amputation rates across the United States.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.