Trial reportCell metabolism2012
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance.
Trial report in Cell metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
190 citing papers in PubMed, 11 syntheses or guidelines pooled it, 374 citations in OpenAlex.
- Pooled it
- The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review.Cardiovascular & hematological disorders drug targets · 2026Pooled it
- Effects of resveratrol supplementation on renal function in adults: a systematic review and dose-response meta-analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Anti-inflammatory mechanism of resveratrol's Triglyceride-lowering effect in hyperlipidemia: a meta-analysis integrated network pharmacology and molecular dynamics simulation.Clinical and experimental medicine · 2025Pooled it
- Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities.International journal of molecular sciences · 2024Pooled it
- Potential of Polyphenols for Improving Sleep: A Preliminary Results from Review of Human Clinical Trials and Mechanistic Insights.Nutrients · 2023Pooled it
- Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review.Frontiers in physiology · 2022Pooled it
- Fine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular health.European journal of nutrition · 2021Pooled it
- Can resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials.European journal of clinical nutrition · 2019Pooled it
- Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies.BMJ (Clinical research ed.) · 2013Pooled it
- No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial.The American journal of clinical nutrition · 2020Trial
- White Sweet Potato as Meal Replacement for Overweight White-Collar Workers: A Randomized Controlled Trial.Nutrients · 2019Trial
- Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes.Molecular metabolism · 2018Trial
- The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans.Adipocyte · 2018Trial
- Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Trial
- High-Protein Intake during Weight Loss Therapy Eliminates the Weight-Loss-Induced Improvement in Insulin Action in Obese Postmenopausal Women.Cell reports · 2016Trial
- Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity.Cell metabolism · 2016 · on this mapTrial
- Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation.Diabetes · 2015Trial
130 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Resveratrol has been reported to improve metabolic function in metabolically abnormal rodents and humans, but it has not been studied in nonobese people with normal glucose tolerance. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the metabolic effects of 12 weeks of resveratrol supplementation (75 mg/day) in nonobese, postmenopausal women with normal glucose tolerance. Although resveratrol supplementation increased plasma resveratrol concentration, it did not change body composition, resting metabolic rate, plasma lipids, or inflammatory markers. A two-stage hyperinsulinemic-euglycemic clamp procedure, in conjunction with stable isotopically labeled tracer infusions, demonstrated that resveratrol did not increase liver, skeletal muscle, or adipose tissue insulin sensitivity. Consistent with the absence of in vivo metabolic effects, resveratrol did not affect its putative molecular targets, including AMPK, SIRT1, NAMPT, and PPARGC1A, in either skeletal muscle or adipose tissue. These findings demonstrate that resveratrol supplementation does not have beneficial metabolic effects in nonobese, postmenopausal women with normal glucose tolerance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.