ArticleThe Journal of pediatrics2013
Continuous renal replacement therapy for children ≤10 kg: a report from the prospective pediatric continuous renal replacement therapy registry.
Article in The Journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- The Japanese clinical practice guideline for acute kidney injury 2016.Clinical and experimental nephrology · 2018Guideline
- Association Between Fluid Balance and Outcomes in Critically Ill Children: A Systematic Review and Meta-analysis.JAMA pediatrics · 2018Pooled it
- Pharmacokinetic assessment in patients receiving continuous RRT: perspectives from the Kidney Health Initiative.Clinical journal of the American Society of Nephrology : CJASN · 2015Guideline
- Regional citrate anticoagulation for pediatric CRRT using integrated citrate software and physiological sodium concentration solutions.Pediatric nephrology (Berlin, Germany) · 2014Trial
- Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Review
- Complications and outcomes of children under one year treated with continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Real-world modality selection and outcomes in neonatal kidney replacement therapy: a single-center cohort study.European journal of pediatrics · 2026Article
- Dialysis modality and mortality of the Contemporary Infant and Neonatal Dialysis (COINED) Cohort: a Pediatric Nephrology Research Consortium (PNRC) study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Continuous Kidney Replacement Therapy in Pediatric Intensive Care: A Practical Guide for Clinicians.Indian pediatrics · 2026Review
- First experience of hemadsorption with HA60 cartridges in newborns and small infants with septic shock: a case series.Frontiers in pediatrics · 2026Article
- CytoSorb haemoadsorption in critically ill children: a multicentre observational study on feasibility, safety, and outcomes, the CYTOPED study.Annals of intensive care · 2026Article
- Renal Replacement Therapy in Pediatric Cardiac Intensive Care: A Retrospective Analysis of Modalities, Outcomes, and Prognostic Factors.Journal of clinical medicine · 2025Article
- Outcomes of continuous kidney replacement therapy in pediatric patients: the impact of timing and predictors of mortality.Pediatric nephrology (Berlin, Germany) · 2025Article
- Liberation from continuous renal replacement therapy due to renal recovery in adults and children: a literature review and Delphi consensus on clinical practice.Critical care (London, England) · 2025Review
- Continuous Renal Replacement Therapy in Critically-Ill Term and Preterm Newborns: A Single-Center Study in Belgrade.Children (Basel, Switzerland) · 2025Article
- AEIOU strategy for continuous renal replacement therapy in infants <10 kg: a practical and educational framework.Frontiers in pediatrics · 2025Review
- Characteristics and outcomes of children ≤ 10 kg receiving continuous kidney replacement therapy: a WE-ROCK study.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Congenital Diaphragmatic Hernia and Congenital Nephrotic Syndrome in a Low-Birth-Weight Infant: A Case Report.Case reports in pediatrics · 2025Article
- Provision of continuous renal replacement therapy in children in intensive care in Australia and New Zealand.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Effectiveness and feasibility of continuous renal replacement therapy for acute kidney injury in neonates weighing 3 kg or less: a two-centre, retrospective study.BMJ paediatrics open · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 12 institutions in 1 country.
Funding
Abstract
objectiveTo report circuit characteristics and survival analysis in children weighing ≤10 kg enrolled in the Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry. STUDY
designWe conducted prospective cohort analysis of the ppCRRT Registry to: (1) evaluate survival differences in children ≤10 kg compared with other children; (2) determine demographic and clinical differences between surviving and non-surviving children ≤10 kg; and (3) describe continuous renal replacement therapy (CRRT) circuit characteristics differences in children ≤5 kg versus 5-10 kg.
resultsThe ppCRRT enrolled 84 children ≤10 kg between January 2001 and August 2005 from 13 US tertiary centers. Children ≤10 kg had lower survival rates than children >10 kg (36/84 [43%] versus 166/260 [64%]; P < .001). In children ≤10 kg, survivors were more likely to have fewer days in intensive care unit prior to CRRT, lower Pediatric Risk of Mortality 2 scores at intensive care unit admission and lower mean airway pressure (P(aw)), higher urine output, and lower percent fluid overload (FO) at CRRT initiation. Adjusted regression analysis revealed that Pediatric Risk of Mortality 2 scores, FO, and decreased urine output were associated with mortality. Compared with circuits from children 5-10 kg at CRRT initiation, circuits from children ≤5 kg more commonly used blood priming for initiation, heparin anticoagulation, and higher blood flows/effluent flows for body weight.
conclusionMortality is more common in children who are ≤10 kg at the time of CRRT initiation. Like other CRRT populations, urine output and FO at CRRT initiation are independently associated with mortality. CRRT prescription differs in small children.
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Registered trials
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