Trial reportJournal of biomechanics2013
Diurnal variations in articular cartilage thickness and strain in the human knee.
Trial report in Journal of biomechanics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 131 citations in OpenAlex.
- A New Stress Test for Knee Joint Cartilage.Scientific reports · 2019Trial
- Acute circulating cartilage-related biomarker responses differ between walking and cycling in healthy young men.European journal of applied physiology · 2026Article
- Supramolecular Engineering of Fluid Pressure in Filamentous Hybrid Double Network Hydrogels for 3D Chondrocyte Culture.Advanced healthcare materials · 2026Article
- A Historical Evaluation of Articular Cartilage Lubrication Studies Reveals Distinct Testing Approach Specific Behaviors.Journal of tribology · 2026Article
- Exploratory analysis of the 2-year changes in knee cartilage thickness and transverse relaxation time (T2) in ACL-injured versus healthy participants.Osteoarthritis and cartilage open · 2026Article
- Analysis of cartilage creep-recovery of human osteoarthritic cartilage.European journal of medical research · 2026Article
- A deep learning-based approach for measuring patellar cartilage deformations from knee MR images.Journal of biomechanics · 2025Article
- Circadian clock communication during homeostasis and ageing.Nature reviews. Molecular cell biology · 2025Review
- Rethinking Osteoarthritis Management: Synergistic Effects of Chronoexercise, Circadian Rhythm, and Chondroprotective Agents.Biomedicines · 2025Article
- Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage.Osteoarthritis and cartilage open · 2025Article
- A Bioinspired Multi-Level Numerical Model of the Tibiofemoral Joint for Biomechanical and Biomimetic Applications.Biomimetics (Basel, Switzerland) · 2025Article
- A synthetic chronogenetic gene circuit for programmed circadian drug delivery.Nature communications · 2025Article
- Synthetic 3D printed tibial plateau with gradient material properties for biomechanical accuracy.Frontiers in bioengineering and biotechnology · 2025Article
- Walking recovers cartilage compressive strain in vivo.Osteoarthritis and cartilage open · 2024Article
- Morphologic Response in Femoral Cartilage During and After 40-Minute Treadmill Running.Journal of athletic training · 2024Article
- Exogenous Collagen Crosslinking is Highly Detrimental to Articular Cartilage Lubrication.Journal of biomechanical engineering · 2024Article
- Femoral cartilage ultrasound echo-intensity is a valid measure of cartilage composition.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Influence of running on femoroacetabular joint bone-to-bone distances.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Ultrasound Measurement of Femoral Articular Cartilage Thickness Before and After Marathon Running.Cureus · 2024Article
- The Influence of Weather Conditions on the Diurnal Variation in Range of Motion in Older Adults with Knee Osteoarthritis.Journal of clinical medicine · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Due to the biphasic viscoelastic nature of cartilage, joint loading may result in deformations that require times on the order of hours to fully recover. Thus, cartilaginous tissues may exhibit cumulative strain over the course of each day. The goal of this study was to assess the magnitude and spatial distribution of strain in the articular cartilage of the knee with daily activity. Magnetic resonance (MR) images of 10 asymptomatic subjects (six males and four females) with mean age of 29 years were obtained at 8:00 AM and 4:00 PM on the same day using a 3T magnet. These images were used to create 3D models of the femur, tibia, and patella from which cartilage thickness distributions were quantified. Cartilage thickness generally decreased from AM to PM in all areas except the patellofemoral groove and was associated with significant compressive strains in the medial condyle and tibial plateau. From AM to PM, cartilage of the medial tibial plateau exhibited a compressive strain of -5.1±1.0% (mean±SEM) averaged over all locations, while strains in the lateral plateau were slightly lower (-3.1±0.6%). Femoral cartilage showed an average strain of -1.9±0.6%. The findings of this study show that human knee cartilage undergoes diurnal changes in strain that vary with site in the joint. Since abnormal joint loading can be detrimental to cartilage homeostasis, these data provide a baseline for future studies investigating the effects of altered biomechanics on diurnal cartilage strains and cartilage physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.