ArticleBiochemistry2012
A role for G-proteins in directing G-protein-coupled receptor-caveolae localization.
Article in Biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Heterotrimeric G proteins containing Gβ1γ2 subunits exhibit subtype-specific mobility differences in live cells.PloS one · 2026Article
- Caveolin-1 Regulates Parathyroid Hormone (PTH)-Related Protein (PTHrP) Actions on PTH Receptor Type 1 in Bone Cells.Journal of cellular physiology · 2025Article
- Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism.The FEBS journal · 2025Article
- Interplay between caveolin-1 and mineralocorticoid receptor in cardiometabolic disease.The Journal of endocrinology · 2024Review
- Gq Signaling in Autophagy Control: Between Chemical and Mechanical Cues.Antioxidants (Basel, Switzerland) · 2022Review
- Deformation of caveolae impacts global transcription and translation processes through relocalization of cavin-1.The Journal of biological chemistry · 2022Article
- Polarized Proteins in Endothelium and Their Contribution to Function.Journal of vascular research · 2021Review
- Caveolin1 Tyrosine-14 Phosphorylation: Role in Cellular Responsiveness to Mechanical Cues.The Journal of membrane biology · 2020Review
- Cell shape regulates subcellular organelle location to control early CaScientific reports · 2020Article
- Regulation of bifunctional proteins in cells: Lessons from the phospholipase Cβ/G protein pathway.Protein science : a publication of the Protein Society · 2020Review
- Components of the GTraffic (Copenhagen, Denmark) · 2020Article
- GPCRs, G Proteins, and Their Impact on β-cell Function.Comprehensive Physiology · 2020Review
- Nitrosative stress uncovers potent βAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning.Scientific reports · 2017Article
- Super-resolution Visualization of Caveola Deformation in Response to Osmotic Stress.The Journal of biological chemistry · 2017Article
- Dexmedetomidine may upregulate the expression of caveolin‑1 in lung tissues of rats with sepsis and improve the short‑term outcome.Molecular medicine reports · 2017Article
- Versatile Functions of Caveolin-1 in Aging-related Diseases.Chonnam medical journal · 2017Review
- The Breast Cancer Susceptibility Gene Product (γ-Synuclein) Alters Cell Behavior through its [corrected] Interaction with Phospholipase Cβ.Cellular signalling · 2016Article
- Osmotic Stress Reduces Ca2+ Signals through Deformation of Caveolae.The Journal of biological chemistry · 2015Article
- Studying GPCR/cAMP pharmacology from the perspective of cellular structure.Frontiers in pharmacology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Caveolae are membrane domains that may influence cell signaling by sequestering specific proteins such as G-protein-coupled receptors (GPCRs). While previous reports largely show that Gα(q) subunits, but not other G-proteins, interact strongly with the caveolae protein, Caveolin-1 (Cav1), the inclusion of GPCRs in caveolae is controversial. Here, we have used fluorescence methods to determine the effect of caveolae on the physical and functional properties of two GPCRs that have been reported to reside in caveolae, bradykinin receptor type 2 (B(2)R), which is coupled to Gα(q), and the μ-opioid receptor (μOR), which is coupled to Gα(i). While caveolae do not affect cAMP signals mediated by μOR, they prolong Ca(2+) signals mediated by B(2)R. In A10 cells that endogenously express B(2)R and Cav1, downregulation of Cav1 ablates the prolonged recovery seen upon bradykinin stimulation in accord with the idea that the presence of caveolae prolongs Gα(q) activation. Immunofluorescence and Förster resonance energy transfer (FRET) studies show that a significant fraction of B(2)R resides at or close to caveolae domains while none or very little μOR resides in caveolae domains. The level of FRET between B(2)R and caveolae is reduced by downregulation of Gα(q) or by addition of a peptide that interferes with Gα(q)-Caveolin-1 interactions, suggesting that Gα(q) promotes localization of B(2)R to caveolae domains. Our results lead to the suggestion that Gα(q) can localize its associated receptors to caveolae domains to enhance their signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.