ReviewArchives of Iranian medicine2012
Polycyclic aromatic hydrocarbons and esophageal squamous cell carcinoma.
Review in Archives of Iranian medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Biomass fuel as a risk factor for esophageal squamous cell carcinoma: a systematic review and meta-analysis.Environmental health : a global access science source · 2019Pooled it
- Association between indoor air pollution and risk of oesophageal cancer: a Chinese population-based case-control study.BMJ public health · 2026Article
- Toxicological impact of benzo[a]pyrene on esophageal cancer: an integrated analysis via network toxicology, machine learning, and molecular docking.Frontiers in immunology · 2026Article
- Esophageal and Head and Neck Cancer Patients Attending Ocean Road Cancer Institute in Tanzania from 2019 to 2021: An Observational Study.International journal of environmental research and public health · 2023Observational
- Contributing factors common to COVID‑19 and gastrointestinal cancer.Oncology reports · 2022Review
- Predictive MERRA-2 aerosol diagnostic model for oral, oropharyngeal and laryngeal cancer caused by air pollution in Thai population.Toxicology reports · 2022Article
- E-waste polycyclic aromatic hydrocarbon (PAH) exposure leads to child gut-mucosal inflammation and adaptive immune response.Environmental science and pollution research international · 2021Article
- Review
- Epidemiology of esophageal cancer: update in global trends, etiology and risk factors.Clinical journal of gastroenterology · 2020Review
- Gender Differences in Oesophageal Squamous Cell Carcinoma in a South African Tertiary Hospital.International journal of environmental research and public health · 2020Article
- GSTs polymorphisms are associated with epigenetic silencing of CDKN2A gene in esophageal squamous cell carcinoma.Environmental science and pollution research international · 2020Article
- Polycyclic aromatic hydrocarbons (PAHs) and esophageal carcinoma in Handan-Xingtai district, North China: a preliminary study based on cancer risk assessment.Environmental monitoring and assessment · 2020Article
- Household Fuel Use and the Risk of Gastrointestinal Cancers: The Golestan Cohort Study.Environmental health perspectives · 2020Article
- 10-Year Trends in Dietary Intakes in the High- and Low-Risk Areas for Esophageal Cancer: A Population-Based Ecological Study in Northern Iran.Middle East journal of digestive diseases · 2020Article
- Article
- Dietary food groups intake and cooking methods associations with pancreatic cancer: a case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2015Article
- Levels of PAH-DNA adducts in cord blood and cord tissue and the risk of fetal neural tube defects in a Chinese population.Neurotoxicology · 2015Article
- Cancer stem cell detection and isolation.Medical oncology (Northwood, London, England) · 2014Review
- CYP1A1 and CYP2E1 genotypes and risk of esophageal squamous cell carcinoma in a high-incidence region, Kashmir.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Correlation of predisposing factors and Esophageal Malignancy in high risk population of Baluchistan.Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Esophageal cancer (EC) is the 8th most common cancer and the 6th most frequent cause of cancer mortality worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common type of EC. Exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested as a risk factor for developing ESCC. In this paper we will review different aspects of the relationship between PAH exposure and ESCC. PAHs are a group of compounds that are formed by incomplete combustion of organic matter. Studies in humans have shown an association between PAH exposure and development of ESCC in many populations. The results of a recent case-control study in a high risk population in northeastern Iran showed a dramatic dose-response relationship between PAH content in non-tumor esophageal tissue (the target tissue for esophageal carcinogenesis) and ESCC case status, consistent with a causal role for PAH exposure in the pathogenesis of ESCC. Identifying the main sources of exposure to PAHs may be the first and most important step in designing appropriate PAH-reduction interventions for controlling ESCC, especially in high risk areas. Coal smoke and drinking mate have been suggested as important modifiable sources of PAH exposure in China and Brazil, respectively. But the primary source of exposure to PAHs in other high risk areas for ESCC, such as northeastern Iran, has not yet been identified. Thus, environmental studies to determining important sources of PAH exposure should be considered as a high priority in future research projects in these areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.