ArticleChemistry & biology2012
Convergent evolution of adenosine aptamers spanning bacterial, human, and random sequences revealed by structure-based bioinformatics and genomic SELEX.
Article in Chemistry & biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Discovery of a G-rich ultra stable human ncRNA G-quadruplex that binds ATP.Non-coding RNA research · 2026Article
- Rapid discovery of functional RNA domains.Nucleic acids research · 2025Article
- Emergence of ATP- and GTP-Binding Aptamers from Single RNA Sequences by Error-Prone Replication and Selection.ChemSystemsChem · 2023Article
- Discovering riboswitches: the past and the future.Trends in biochemical sciences · 2023Review
- Phenotype Bias Determines How Natural RNA Structures Occupy the Morphospace of All Possible Shapes.Molecular biology and evolution · 2022Article
- Transliteration of synthetic genetic enzymes.Nucleic acids research · 2021Article
- Hovlinc is a recently evolved class of ribozyme found in human lncRNA.Nature chemical biology · 2021Article
- Big on Change, Small on Innovation: Evolutionary Consequences of RNA Sequence Duplication.Journal of molecular evolution · 2019Article
- Mammalian RNA switches: Molecular rheostats in gene regulation, disease, and medicine.Computational and structural biotechnology journal · 2019Review
- Review
- Allosteric Modulation of the Faecalibacterium prausnitzii Hepatitis Delta Virus-like Ribozyme by Glucosamine 6-Phosphate: The Substrate of the Adjacent Gene Product.Biochemistry · 2017Article
- Multiplex Aptamer Discovery through Apta-Seq and Its Application to ATP Aptamers Derived from Human-Genomic SELEX.ACS chemical biology · 2017Article
- G-quadruplex-based aptamers against protein targets in therapy and diagnostics.Biochimica et biophysica acta. General subjects · 2017Review
- A human microRNA precursor binding to folic acid discovered by small RNA transcriptomic SELEX.RNA (New York, N.Y.) · 2016Article
- Improving the odds: Influence of starting pools on in vitro selection outcomes.Methods (San Diego, Calif.) · 2016Review
- RNA motif search with data-driven element ordering.BMC bioinformatics · 2016Article
- Bacterial Riboswitches and Ribozymes Potently Activate the Human Innate Immune Sensor PKR.ACS chemical biology · 2016Article
- A DNAzyme requiring two different metal ions at two distinct sites.Nucleic acids research · 2016Article
- Elucidating the molecular architecture of adaptation via evolve and resequence experiments.Nature reviews. Genetics · 2015Review
- Widespread occurrence of organelle genome-encoded 5S rRNAs including permuted molecules.Nucleic acids research · 2014Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
Aptamers are structured macromolecules in vitro evolved to bind molecular targets, whereas in nature they form the ligand-binding domains of riboswitches. Adenosine aptamers of a single structural family were isolated several times from random pools, but they have not been identified in genomic sequences. We used two unbiased methods, structure-based bioinformatics and human genome-based in vitro selection, to identify aptamers that form the same adenosine-binding structure in a bacterium, and several vertebrates, including humans. Two of the human aptamers map to introns of RAB3C and FGD3 genes. The RAB3C aptamer binds ATP with dissociation constants about 10 times lower than physiological ATP concentration, while the minimal FGD3 aptamer binds ATP only cotranscriptionally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.