Evidence map›Paper›PMID 23102214›Full record

ArticleChemistry & biology2012

Controlling radicals in the powerhouse: development of MitoSOD.

Tanecia Mitchell, Balu K Chacko, Victor Darley-Usmar

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. A non-toxic fluorogenic dye for mitochondria labeling.Biochimica et biophysica acta · 2013
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tanecia Mitchell
Balu K Chacko
Victor Darley-Usmar
University of Alabama at Birmingham · US

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill · 2000 to 2026
$31.9M
TRAINING IN CELLULAR PHYSIOLOGY MEMBRANE TRANSPORTT32DK007545 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M · 1987 to 2023
$4.5M
Ethanol toxicity and NO-dependent mitochondrial damageR01AA013395 · NIAAA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DARLEY-USMAR, VICTOR M · 2002 to 2011
$2.9M
Development of mitochondrially targeted antioxidants for diabetic therapyR01DK075865 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DARLEY-USMAR, VICTOR M · 2007 to 2010
$1.5M
Development of mitochondrially targeted antioxidants for diabetic therapyR56DK075865 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DARLEY-USMAR, VICTOR M · 2006 to 2006
$182k
NIAAA NIH HHS AA13395NIAAA NIH HHS R01 AA013395NIDDK NIH HHS DK075865NIDDK NIH HHS P30 DK056336NIDDK NIH HHS R01 DK075865NIDDK NIH HHS R56 DK075865NIDDK NIH HHS T32 DK007545
6 · The paper itself

Abstract

Investigators in the redox biology field have long recognized the unique role mitochondrial superoxide generation plays in physiological signaling and in dysregulated bioenergetic dysfunction. Pharmacological manipulation has been challenging, and in this issue of Chemistry & Biology, Kelso and colleagues present the synthesis and characterization of a novel mitochondrial-targeted SOD mimetic, MitoSOD.

Identifiers

PMID23102214
PMCPMC3491654
OpenAlexW1977003368

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.