Evidence map›Paper›PMID 23101620›Full record

ArticleCell2012

A tollgate for typhoid.

Ferric C Fang, Andreas J Bäumler

Abstract readComment
In one paragraph

Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Host specificity of bacterial pathogens.Cold Spring Harbor perspectives in medicine · 2013
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ferric C FangDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195-7735, USA. fcfang@uw.edu
Andreas J Bäumler

Funding

Virulence Factors of SalmonellaR01AI044170 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI BAUMLER, ANDREAS J · 1999 to 2022
$8.5M
Prevalence and Correlates of NTS Bacteremia, Diarrhea and Carriage in KenyaU19AI090882 · NIAID · UNIVERSITY OF WASHINGTON · PI KEMNER, JOHN M · 2010 to 2014
$5.6M
Host Interactions of Salmonella typhimuriumR01AI076246 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ADAMS, LESLIE GARRY, BAUMLER, ANDREAS J · 2009 to 2013
$2.7M
A Humanized Mouse Model of Typhoid FeverR21AI091966 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2011 to 2012
$429k
NIAID NIH HHS AI44170NIAID NIH HHS AI76246NIAID NIH HHS AI90882NIAID NIH HHS AI91966NIAID NIH HHS R01 AI044170NIAID NIH HHS R01 AI076246NIAID NIH HHS R21 AI091966NIAID NIH HHS U19 AI090882
6 · The paper itself

Abstract

Humans are uniquely susceptible to typhoid fever caused by infection with Salmonella enterica serovar Typhi. Mathur et al. now report that mice lacking Toll-like receptor 11, which is absent in humans, can be lethally infected with S. Typhi, a breakthrough that promises to speed the development of better vaccines.

Identifiers

PMID23101620
PMCPMC6524972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.