ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2013
Possible reinforcement enhancing effects of bupropion during initial smoking abstinence.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Possible New Symptoms of Tobacco Withdrawal II: Anhedonia-A Systematic Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Pooled it
- Does Extended Pre Quit Bupropion Aid in Extinguishing Smoking Behavior?Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Trial
- Reinforcement Enhancing Effects of Nicotine Via Patch and Nasal Spray.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Smoking-induced affect modulation in nonwithdrawn smokers with posttraumatic stress disorder, depression, and in those with no psychiatric disorder.Journal of abnormal psychology · 2017Article
- Nicotine Acutely Enhances Reinforcement from Non-Drug Rewards in Humans.Frontiers in psychiatry · 2017Review
- Reinforcement enhancing effects of acute nicotine via electronic cigarettes.Drug and alcohol dependence · 2015Article
- Examination of the metabolite hydroxybupropion in the reinforcing and aversive stimulus effects of nicotine in rats.Psychopharmacology · 2015Article
- The effects of nicotine dependence and acute abstinence on the processing of drug and non-drug rewards.Psychopharmacology · 2015Article
- Sensory reinforcement-enhancing effects of nicotine via smoking.Experimental and clinical psychopharmacology · 2014Article
- Reward and affective regulation in depression-prone smokers.Biological psychiatry · 2014Article
- Applications and implications of heparin and protamine in tissue engineering and regenerative medicine.BioMed research international · 2014Review
- Influence of reinforcer magnitude and nicotine amount on smoking's acute reinforcement enhancing effects.Drug and alcohol dependence · 2013Article
- Reinforcement enhancing effects of nicotine via smoking.Psychopharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionDue to a drop in nicotine, smoking cessation may attenuate reinforcement from sensory stimuli unrelated to nicotine intake. Recent rodent research suggests that bupropion may reverse this attenuation, perhaps helping explain its efficacy in aiding cessation.
methodsIn a within-subjects, crossover study, smokers responded on a simple computer task for brief music reward available on a progressive ratio 50% schedule. Testing was done on three separate occasions: after ad lib smoking during prequit baseline and on the first day of two brief quit attempts while taking bupropion or placebo, in counter-balanced order. Number of operant responses was the measure of reinforcement. To more clearly assess abstinence and medication effects, those meeting 24-hr abstinence criteria (CO < 5 ppm; n = 5) or clearly failing to abstain (CO > 10 ppm; n = 5) during both medication conditions were compared.
resultsAmong abstainers, repeated measures ANOVA showed that reinforced responding decreased by nearly 50% from baseline after quitting on placebo (p = .03), while responding after quitting on bupropion was similar to that during baseline (-17%; p = .20). In contrast, those unable to abstain showed virtually identical reinforced responding due to either medication or baseline.
conclusionsThese exploratory findings confirm that responding for a reward unrelated to smoking decreases after abstinence and are consistent with animal research showing bupropion effects on enhancing reinforced responding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.