ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Erbin is required for myelination in regenerated axons after injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Erbin Regulates Neuronal Hyperexcitability and Seizure Susceptibility in Temporal Lobe Epilepsy.Neuroscience bulletin · 2026Article
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- Multiscale proteomic modeling reveals protein networks driving Alzheimer's disease pathogenesis.Cell · 2025Article
- Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile.Cellular and molecular neurobiology · 2023Article
- Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection.Zoological research · 2022Article
- Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers.Cell & bioscience · 2022Article
- Super-resolved fluorescence imaging of peripheral nerve.Scientific reports · 2022Article
- Lessons from Injury: How Nerve Injury Studies Reveal Basic Biological Mechanisms and Therapeutic Opportunities for Peripheral Nerve Diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Article
- The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease.The FEBS journal · 2021Review
- Fresh human amniotic membrane effectively promotes the repair of injured common peroneal nerve.Neural regeneration research · 2019Article
- Precocious myelination in a mouse model of autism.Translational psychiatry · 2019Article
- Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.JCI insight · 2019Article
- Experimental Characterization of the Chronic Constriction Injury-Induced Neuropathic Pain Model in Mice.Neurochemical research · 2019Article
- Article
- Long-Term Denervated Rat Schwann Cells Retain Their Capacity to Proliferate and to Myelinate AxonsFrontiers in cellular neuroscience · 2018Article
- Activation of Neuregulin 1/ErbB Signaling Is Involved in the Development of TOCP-Induced Delayed Neuropathy.Frontiers in molecular neuroscience · 2018Article
- Muscle Yap Is a Regulator of Neuromuscular Junction Formation and Regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Familial 5q12.3 Microdeletion: Evidence for a Locus Associated with Epilepsy.Molecular syndromology · 2017Article
- Dual specificity phosphatase 15 regulates Erk activation in Schwann cells.Journal of neurochemistry · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Neuregulin 1 (NRG1) is an axon-derived factor that is critical for Schwann cell (SC) development and myelinogenesis in a manner dependent on transmembrane tyrosine kinases ErbB2 and ErbB3. Recent studies suggest that NRG1 signaling plays a role in remyelination of regenerated nerves after injury. In this study, we investigated the role of Erbin, a protein that interacts with ErbB2 in remyelination of injured nerves. We show that Erbin expression increased dramatically in injured nerves. Myelinated axons were fewer, and g-ratios of those that were myelinated were increased in erbin(-/-) mice, which were impaired in functional recovery from nerve injury. These results indicate a necessary role of Erbin in remyelination of regenerating axons. Erbin ablation had little effect on numbers of BrdU-labeled and TUNEL-labeled SCs, suggesting mechanisms independent of altered proliferation or apoptosis. We demonstrated that Erbin mutant mice were impaired in raising or maintaining the levels of ErbB2 and in producing NRG1 in axons. Together, these observations demonstrate that Erbin is required for remyelination of regenerated axons after injury, probably by regulating ErbB2 and NRG1 levels, identifying a novel player in regulating remyelination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.