ReviewCurrent osteoporosis reports2012
HIV infection and osteoporosis: pathophysiology, diagnosis, and treatment options.
Review in Current osteoporosis reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03930992 (Efficacy of 4 mg Zoledronic Acid Plus Colaren vs 4mg Zoledronic Acid + Conventional Treatment for Secondary Osteoporosis in HIV Positive and Negative Men), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of 4 mg Zoledronic Acid Plus Colaren vs 4mg Zoledronic Acid + Conventional Treatment for Secondary Osteoporosis in HIV Positive and Negative Men
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Relationships Between Physical Activity and Bone Density in People Living with HIV: Results from the SATURN-HIV Study.The Journal of the Association of Nurses in AIDS Care : JANACTrial
- Bone Health in People Living with HIV: From Pathophysiology to Practical Management.Infection & chemotherapy · 2026Review
- Narrative Review on the Management of Neck of Femur Fractures in People Living with HIV: Challenges, Complications, and Long-Term Outcomes.Microorganisms · 2025Review
- Joint replacement and human immunodeficiency virus.World journal of virology · 2023Review
- Bilateral symmetrical stress fractures of femoral neck in HIV patient: case report and brief review of literature.BJR case reports · 2022Article
- Article
- Human immunodeficiency virus in total hip arthroplasty.EFORT open reviews · 2020Review
- The seroprevalence of HIV in patients undergoing lower limb Total Joint Arthroplasty (TJA) in South Africa.SICOT-J · 2020Article
- Elderly HIV-positive women: A gender-based analysis from the Multicenter Italian "GEPPO" Cohort.PloS one · 2019Article
- Premature Spinal Bone Loss in Women Living with HIV is Associated with Shorter Leukocyte Telomere Length.International journal of environmental research and public health · 2018Article
- Antiretroviral Therapy, Especially Efavirenz, Is Associated with Low Bone Mineral Density in HIV-Infected South Africans.PloS one · 2015Article
- [Interference immune system and bone repair].Zeitschrift fur Rheumatologie · 2014Article
- Relationships between inflammation, immune activation, and bone health among HIV-infected adults on stable antiretroviral therapy.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Osteoporosis in Human Immunodeficiency Virus Patients - An Emerging Clinical Concern.European endocrinology · 2014Review
- Association of Blood Biomarkers of Bone Turnover in HIV-1 Infected Individuals Receiving Anti-Retroviral Therapy (ART).Journal of AIDS & clinical researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the population with HIV continues to age, specialists in HIV care are increasingly encountering chronic health conditions, which now include osteoporosis, osteopenia, and fragility fractures. The pathophysiology of the bone effects of HIV infection is complex and includes traditional risk factors for bone loss as well as specific effects due to the virus itself, chronic inflammation, and HAART. Examining risk factors for low bone density and screening of certain patients is suggested, and consideration should be given to treatment for those considered high risk for fracture.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.