ArticleJournal of perinatology : official journal of the California Perinatal Association2013
Prospective crossover comparison between NAVA and pressure control ventilation in premature neonates less than 1500 grams.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Crossover Comparison of Work of Breathing During Non-invasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) in Premature Neonates
Breathing Pattern Variability in Preterm Infants: Effect of Non-invasive Neurally Adjusted Ventilatory Assist (NAVA-NIV) Versus Nasal Intermittent Positive Pressure Ventilation (PC-NIV), a Crossover Study
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Neurally adjusted ventilatory assist compared to other forms of triggered ventilation for neonatal respiratory support.The Cochrane database of systematic reviews · 2017Pooled it
- Comparison of extubation success using noninvasive positive pressure ventilation (NIPPV) versus noninvasive neurally adjusted ventilatory assist (NI-NAVA).Journal of perinatology : official journal of the California Perinatal Association · 2020Trial
- Proportional assist ventilation (PAV) versus neurally adjusted ventilator assist (NAVA): effect on oxygenation in infants with evolving or established bronchopulmonary dysplasia.European journal of pediatrics · 2020Trial
- The impact of neurally adjusted ventilatory assist mode on respiratory severity score and energy expenditure in infants: a randomized crossover trial.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- Feasibility and physiological effects of noninvasive neurally adjusted ventilatory assist in preterm infants.Pediatric research · 2017Trial
- Crossover study of assist control ventilation and neurally adjusted ventilatory assist.European journal of pediatrics · 2017Trial
- Neurally adjusted ventilatory assist (NAVA) in preterm newborn infants with respiratory distress syndrome-a randomized controlled trial.European journal of pediatrics · 2016Trial
- Perspectives of medical staff on respiratory management with neurally adjusted ventilatory assist in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Respiratory physiological changes post initiation of neurally adjusted ventilatory assist in preterm infants with evolving or established bronchopulmonary dysplasia.European journal of pediatrics · 2025Article
- Comparison of neurally adjusted ventilatory assist and synchronized intermittent mandatory ventilation in preterm infants after patent ductus arteriosus ligation: a retrospective study.BMC pediatrics · 2024Article
- Article
- Optimizing Invasive Neonatal Respiratory Care: A Systematic Review of Invasive Neurally Adjusted Ventilatory Assist.Healthcare (Basel, Switzerland) · 2024Review
- Noninvasive Neurally Adjusted Ventilation versus Nasal Continuous or Intermittent Positive Airway Pressure for Preterm Infants: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Implementation of neurally adjusted ventilatory assist and high flow nasal cannula in very preterm infants in a tertiary level NICU.Pediatric pulmonology · 2022Article
- Evaluating peak inspiratory pressures and tidal volume in premature neonates on NAVA ventilation.European journal of pediatrics · 2021Article
- Utilization of Neurally Adjusted Ventilatory Assist (NAVA) Mode in Infants and Children Undergoing Congenital Heart Surgery: A Retrospective Review.Pediatric cardiology · 2019Article
- Neurally adjusted ventilator assist in very low birth weight infants: Current status.World journal of methodology · 2015Article
- Advances in respiratory support for high risk newborn infants.Maternal health, neonatology and perinatology · 2015Article
- Monitoring diaphragm electrical activity and the detection of congenital central hypoventilation syndrome in a newborn.Journal of perinatology : official journal of the California Perinatal Association · 2013Article
- Neurally adjusted ventilatory assist in pediatrics: why, when, and how?Revista Brasileira de terapia intensivaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeurally adjusted ventilatory assist (NAVA) synchronizes spontaneous respiratory effort with mechanical ventilation. Electrodes detect the electrical activity of the diaphragm (Edi) and transmit this information to the ventilator, allowing the patient to determine their own respiratory rate (RR), peak pressures, and inspiratory and expiratory times in synchrony with the ventilator. The objective of this study was to evaluate if premature neonates ventilate as effectively on NAVA as compared to pressure control ventilation (PCV). STUDY
designFive ventilated neonates were enrolled (gestational age 25-29 weeks). Each neonate was ventilated on NAVA for 4 h, then switched to PCV for another 4 h. The cycle was repeated three times. Ventilatory parameters were averaged every 30 min to collect eight time points for each ventilatory mode. Data were analyzed using the mixed effects model procedure, utilizing the least-squares means (P<0.05).
resultWhen compared to PCV, neonates ventilated with NAVA had lower peak inspiratory pressures (PIP), fraction of inspired oxygen (FiO2), transcutaneous PCO2 Edi peak and RR. There was an increase in expiratory tidal volume (TV), compliance and Edi minimum. Despite lower PIP and RR, partial pressure of CO2 (PCO2) was lower when ventilated on NAVA. There was no difference in mean airway pressure.
conclusionPremature neonates ventilated with NAVA required less PIP, FiO2 and RR to achieve lower PCO2 and better compliance compared with PCV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.