ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2013
Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- The case for space as a model of accelerated aging.Nature aging · 2026Review
- The Heart in Space: Effects of Microgravity on Different Cell Types and Their Functions in the Cardiovascular System.Biomedicines · 2025Review
- Modelling large scale artery haemodynamics from the heart to the eye in response to simulated microgravity.NPJ microgravity · 2024Article
- The Effects of Simulated and Real Microgravity on Vascular Smooth Muscle Cells.Gravitational and space research : publication of the American Society for Gravitational and Space Research · 2024Article
- Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart.International journal of molecular sciences · 2021Article
- Meta-Analysis-Assisted Detection of Gravity-Sensitive Genes in Human Vascular Endothelial Cells.Frontiers in cell and developmental biology · 2021Article
- Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures.Frontiers in physiology · 2020Review
- Development of new experimental platform 'MARS'-Multiple Artificial-gravity Research System-to elucidate the impacts of micro/partial gravity on mice.Scientific reports · 2017Article
- Spaceflight-induced synaptic modifications within hair cells of the mammalian utricle.Journal of neurophysiology · 2017Article
- From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions.NPJ microgravity · 2017Article
- Evaluation of rodent spaceflight in the NASA animal enclosure module for an extended operational period (up to 35 days).NPJ microgravity · 2016Article
- Caveolae regulate vasoconstriction of conduit arteries to angiotensin II in hindlimb unweighted rats.The Journal of physiology · 2015Article
- Effects of skeletal unloading on the vasomotor properties of the rat femur principal nutrient artery.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Effects of sex and gender on adaptation to space: cardiovascular alterations.Journal of women's health (2002) · 2014Article
- Up-regulation of ryanodine receptor expression increases the calcium-induced calcium release and spontaneous calcium signals in cerebral arteries from hindlimb unloaded rats.Pflugers Archiv : European journal of physiology · 2014Article
- The effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Mice in Bion-M 1 space mission: training and selection.PloS one · 2014Article
- Article
- Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: implications for elevated cerebral perfusion and intracranial pressure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Following exposure to microgravity, there is a reduced ability of astronauts to augment peripheral vascular resistance, often resulting in orthostatic hypotension. The purpose of this study was to test the hypothesis that mesenteric arteries and veins will exhibit diminished vasoconstrictor responses after spaceflight. Mesenteric arteries and veins from female mice flown on the Space Transportation System (STS)-131 (n=11), STS-133 (n=6), and STS-135 (n=3) shuttle missions and respective ground-based control mice (n=30) were isolated for in vitro experimentation. Vasoconstrictor responses were evoked in arteries via norepinephrine (NE), potassium chloride (KCl), and caffeine, and in veins through NE across a range of intraluminal pressures (2-12 cmH(2)O). Vasoconstriction to NE was also determined in mesenteric arteries at 1, 5, and 7 d postlanding. In arteries, maximal constriction to NE, KCl, and caffeine were reduced immediately following spaceflight and 1 d postflight. Spaceflight also reduced arterial ryanodine receptor-3 mRNA levels. In mesenteric veins, there was diminished constriction to NE after flight. The results indicate that the impaired vasoconstriction following spaceflight occurs through the ryanodine receptor-mediated intracellular Ca(2+) release mechanism. Such vascular changes in astronauts could compromise the maintenance of arterial pressure during orthostatic stress.
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