ArticleThe European physical journal. E, Soft matter2012
Modelling the fluid mechanics of cilia and flagella in reproduction and development.
Article in The European physical journal. E, Soft matter, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 54 citations in OpenAlex.
- Artificial embryonic node elucidates the role of flow in left-right symmetry breaking in vertebrates.Science advances · 2026Article
- Development and application of vibrating dynamic culture system for mouse oocytes and embryos.Frontiers in veterinary science · 2025Article
- Exploring sperm cell motion dynamics: Insights from genetic algorithm-based analysis.Computational and structural biotechnology journal · 2024Article
- Effects of microvibration stimulation on developmental potential of discarded germinal vesicle oocytes of human.Frontiers in endocrinology · 2022Article
- Passively parallel regularized stokeslets.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- RETRACTED: Human sperm uses asymmetric and anisotropic flagellar controls to regulate swimming symmetry and cell steering.Science advances · 2020Article
- From flagellar undulations to collective motion: predicting the dynamics of sperm suspensions.Journal of the Royal Society, Interface · 2018Article
- Bimodal rheotactic behavior reflects flagellar beat asymmetry in human sperm cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Establishment of left-right asymmetry in vertebrate development: the node in mouse embryos.Cellular and molecular life sciences : CMLS · 2013Review
- Active matter.The European physical journal. E, Soft matter · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cilia and flagella are actively bending slender organelles, performing functions such as motility, feeding and embryonic symmetry breaking. We review the mechanics of viscous-dominated microscale flow, including time-reversal symmetry, drag anisotropy of slender bodies, and wall effects. We focus on the fundamental force singularity, higher-order multipoles, and the method of images, providing physical insight and forming a basis for computational approaches. Two biological problems are then considered in more detail: 1) left-right symmetry breaking flow in the node, a microscopic structure in developing vertebrate embryos, and 2) motility of microswimmers through non-Newtonian fluids. Our model of the embryonic node reveals how particle transport associated with morphogenesis is modulated by the gradual emergence of cilium posterior tilt. Our model of swimming makes use of force distributions within a body-conforming finite-element framework, allowing the solution of nonlinear inertialess Carreau flow. We find that a three-sphere model swimmer and a model sperm are similarly affected by shear-thinning; in both cases swimming due to a prescribed beat is enhanced by shear-thinning, with optimal Deborah number around 0.8. The sperm exhibits an almost perfect linear relationship between velocity and the logarithm of the ratio of zero to infinite shear viscosity, with shear-thickening hindering cell progress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.