Evidence map›Paper›PMID 23099234›Full record

ArticleTrends in genetics : TIG2012

The resurgence and genetic implications of New World primates in biomedical research.

Joshua M Ward, Eric J Vallender

Abstract read
In one paragraph

Article in Trends in genetics : TIG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Morphometry and skeletopy of kidneys and renal vessels inBrazilian journal of veterinary medicine · 2023
    Article
  5. Review
  6. Review
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  8. Article
  9. Article
  10. Recently integratedMobile DNA · 2018
    Article
  11. Article
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  18. Review
  19. Sequencing and comparative analysis of the gorilla MHC genomic sequence.Database : the journal of biological databases and curation · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joshua M WardNew England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA.
Eric J Vallender
New England Biolabs (United States) · US

Funding

ZETA CHAIN OF T CELL RECEPTOR INTERACTS W/ NEF OF SIV &HIV2P51RR000168 · NCRR · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WESTMORELAND, SUSAN V. · 1985 to 2011
$139.3M
New England Primate Research Center Base GrantP51OD011103 · OD · HARVARD MEDICAL SCHOOL · PI FLIER, JEFFREY S · 2012 to 2013
$24.7M
Functional genetic evolution of human brain and behaviorR01AA019688 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI VALLENDER, ERIC J. · 2010 to 2014
$1.9M
NCRR NIH HHS P51 RR000168NIAAA NIH HHS AA019688NIAAA NIH HHS R01 AA019688NIH HHS OD011103NIH HHS P51 OD011103
6 · The paper itself

Abstract

There has been a recent resurgence of interest in New World monkeys within the biomedical research community, driven by both the sequencing of the common marmoset (Callithrix jacchus) genome and a growing demand for alternatives to Old World primates. New World monkeys offer attractive advantages over Old World species, including cheaper and simpler husbandry, while still maintaining a greater evolutionary proximity to humans compared with other animal models. Although numerous commonalities across primate species exist, there are also important genetic and reproductive differences that can and should play a critical role in selecting appropriate animal models. Common marmosets in particular have significantly reduced diversity at the major histocompatibility complex (MHC) loci and are born as hematopoietic chimeras. New World primates can make ideal translational models for research, but scientists must necessarily incorporate complete understandings of their genetic and phenotypic differences from humans and other model organisms.

Indexed as

Animal HusbandryAnimalsBiological EvolutionBiomedical ResearchCallithrixChimeraGenetic VariationGenomeHematopoietic Stem CellsHumansMajor Histocompatibility ComplexModels, AnimalPrimatesSaimiri

Identifiers

PMID23099234
PMCPMC3500444
OpenAlexW2079560114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.