ArticleBiomaterials2013
Directing cell migration in continuous microchannels by topographical amplification of natural directional persistence.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Tailoring Cell Behavior and Antibacterial Properties on Zirconia Biomaterials through Femtosecond Laser-Induced Micropatterns and Nanotopography.ACS applied materials & interfaces · 2025Article
- Drop-shaped microgrooves guide unidirectional cell migration for enhanced endothelialization.Nature communications · 2025Article
- Shape of scaffold controlling the direction of cell migration.Biophysics and physicobiology · 2024Article
- A More Biomimetic Cell Migration Assay with High Reliability and Its Applications.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Effect of Geometric Curvature on Collective Cell Migration in Tortuous Microchannel Devices.Micromachines · 2020Article
- Area and Geometry Dependence of Cell Migration in Asymmetric Two-State Micropatterns.Biophysical journal · 2020Article
- Crosshatch nanofiber networks of tunable interfiber spacing induce plasticity in cell migration and cytoskeletal response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Preparation of micro/nanopatterned gelatins crosslinked with genipin for biocompatible dental implants.Beilstein journal of nanotechnology · 2018Article
- Engineering Dynamic Biointerfaces.Current opinion in chemical engineering · 2016Article
- Effective Spatial Separation of PC12 and NIH3T3 Cells by the Microgrooved Surface of Biocompatible Polymer Substrates.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Topography design concept of a tissue engineering scaffold for controlling cell function and fate through actin cytoskeletal modulation.Tissue engineering. Part B, Reviews · 2014Review
- Cells as active particles in asymmetric potentials: motility under external gradients.Biophysical journal · 2014Article
- Protrusion fluctuations direct cell motion.Biophysical journal · 2014Article
- Gradient-free directional cell migration in continuous microchannels.Soft matter · 2013Article
- Rectified cell migration on saw-like micro-elastically patterned hydrogels with asymmetric gradient ratchet teeth.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Discrete micropatterns on biomaterial surfaces can be used to guide the direction of mammalian cell movement by orienting cell morphology. However, guiding cell assembly in three-dimensional scaffolds remains a challenge. Here we demonstrate that the random motions of motile cells can be rectified within continuous microchannels without chemotactic gradients or fluid flow. Our results show that uniform width microchannels with an overhanging zigzag design can induce polarization of NIH3T3 fibroblasts and human umbilical vein endothelial cells by expanding the cell front at each turn. These continuous zigzag microchannels can guide the direction of cell movement even for cells with altered intracellular signals that promote random movement. This approach for directing cell migration within microchannels has important potential implications in the design of scaffolds for tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.