Trial reportJournal of psychiatric research2013
Augmentation of exposure therapy with post-session administration of D-cycloserine.
Trial report in Journal of psychiatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01102803 (Evaluation of the Effects of Post-Session Administration of D-cycloserine On Exposure Therapy Outcomes), which is not on this map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effects of Post-Session Administration of D-cycloserine On Exposure Therapy Outcomes
Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Recent Progress in Virtual Reality Exposure Therapy for Phobias: A Systematic Review.Current psychiatry reports · 2017Pooled it
- A Meta-Analysis of D-Cycloserine in Exposure-Based Treatment: Moderators of Treatment Efficacy, Response, and Diagnostic Remission.The Journal of clinical psychiatry · 2017Pooled it
- D-cycloserine augmentation of behavior therapy for anxiety and obsessive-compulsive disorders: A meta-analysis.PloS one · 2017Pooled it
- Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders.The Cochrane database of systematic reviews · 2015Pooled it
- Does D-cycloserine enhance exposure therapy for anxiety disorders in humans? A meta-analysis.PloS one · 2014Pooled it
- D-Cycloserine augmentation of cognitive behavior therapy for pediatric OCD: Predictors and moderators of outcome.Journal of affective disorders · 2018Trial
- D-cycloserine-augmented one-session treatment of specific phobias in children and adolescents.Brain and behavior · 2018Trial
- Dose timing of D-cycloserine to augment cognitive behavioral therapy for social anxiety: Study design and rationale.Contemporary clinical trials · 2015Trial
- Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data.Cognitive behaviour therapy · 2015Trial
- Effects of post-session administration of methylene blue on fear extinction and contextual memory in adults with claustrophobia.The American journal of psychiatry · 2014Trial
- D-cycloserine enhancement of exposure therapy for social anxiety disorder depends on the success of exposure sessions.Journal of psychiatric research · 2013Trial
- D-cycloserine enhancement of fear extinction is specific to successful exposure sessions: evidence from the treatment of height phobia.Biological psychiatry · 2013Trial
- Enhancing the Efficacy of Exposure Therapy: Translation of Pharmacological Augmentation of Fear Extinction.Annual review of clinical psychology · 2026Review
- A transdiagnostic meta-analysis of acute augmentations to psychological therapy.Nature. Mental health · 2023Article
- Extinction-Based Exposure Therapies Using Virtual Reality.Current topics in behavioral neurosciences · 2023Review
- GluN2B and GluN2A-containing NMDAR are differentially involved in extinction memory destabilization and restabilization during reconsolidation.Scientific reports · 2021Article
- Cognitive behavioural therapy in virtual reality treatments across mental health conditions: a systematic review.Consortium psychiatricum · 2020Review
- Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options.Frontiers in psychiatry · 2020Review
- Differential effects of D-cycloserine and amantadine on motor behavior and DScientific reports · 2019Article
- A precision medicine approach to pharmacological adjuncts to extinction: a call to broaden research.Psychopharmacology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPre-session administration of d-cycloserine (DCS) has been found to augment exposure therapy outcomes in a variety of anxiety disorders. To be able to enhance learning only for successful exposure sessions, it would be beneficial to have the option of administering DCS after rather than before the session, a strategy encouraged by pre-clinical work. We believe the present study is the first published report on the efficacy of post-session administration of DCS in humans.
methodAdults (N = 29) with a DSM-IV diagnosis of acrophobia were randomized to receive two sessions of virtual reality exposure therapy (VRE) in combination with placebo or 50 mg of DCS. Instead of administering the pill prior to each of the sessions, as has been done in extant work, we administered the pill immediately following each session. Measures of acrophobia severity were collected at baseline, at each treatment session, 1-week post-treatment, and at 1-month follow-up.
resultsMixed-effects repeated-measures ANOVAs and GLMMs revealed significant improvement in all outcome measures over time, but no between-group differences were observed. At post-treatment, 63.5% of patients in the placebo condition vs. 60.0% of those in the DCS condition were in remission. At 1-month follow up, 63.4% of those in the placebo condition vs. 66.6% of those in the DCS condition were in remission.
conclusionsThese findings do not support the application of post-session DCS administration for augmenting the efficacy of exposure-based treatments. Possible reasons for these findings are discussed. TRIAL REGISTRY: The Trial is registered at ClinicalTrials.gov (NCT01102803).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.