ArticlePhysiological research2012
Fatty acid composition of adipose tissue triglycerides after weight loss and weight maintenance: the DIOGENES study.
Article in Physiological research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Profiling of Endogenous and Gut Microbial Metabolites to Indicate Metabotype-Specific Dietary Responses: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Increase in adipose tissue linoleic acid of US adults in the last half century.Advances in nutrition (Bethesda, Md.) · 2015Pooled it
- Adipocyte size, adipose tissue calories, and circulating adipokines, before and after diet-induced weight loss in humans.Endocrine · 2024Trial
- Article
- Review
- Statement on additional scientific evidence in relation to the essential composition of total diet replacement for weight control.EFSA journal. European Food Safety Authority · 2021Article
- Sample Preparation Methods for Lipidomics Approaches Used in Studies of Obesity.Molecules (Basel, Switzerland) · 2020Review
- The fatty acid profile of adipose tissue as a predictor of the ponderal and inflammatory response in adult women six years after bariatric surgery.Lipids in health and disease · 2020Article
- FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression.International journal of obesity (2005) · 2019Article
- In vivo triglyceride composition of abdominal adipose tissue measured byJournal of magnetic resonance imaging : JMRI · 2017Article
- The Role of the Novel Lipokine Palmitoleic Acid in Health and Disease.Advances in nutrition (Bethesda, Md.) · 2017Review
- Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss.International journal of endocrinology · 2017Article
- Seven Countries Study cohort in Crete, Greece: gluteal adipose-tissue fatty-acid profiles of survivors, at 2010.Public health nutrition · 2016Article
- The Effect of Marine Derived n-3 Fatty Acids on Adipose Tissue Metabolism and Function.Journal of clinical medicine · 2015Review
- Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.Scientific reports · 2015Article
- The role of higher protein diets in weight control and obesity-related comorbidities.International journal of obesity (2005) · 2015Review
- System model network for adipose tissue signatures related to weight changes in response to calorie restriction and subsequent weight maintenance.PLoS computational biology · 2015Article
- Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A.Biochimica et biophysica acta · 2014Article
- Fatty acid metabolism: Implications for diet, genetic variation, and disease.Food bioscience · 2013Article
- Oxidative stress and the ageing endocrine system.Nature reviews. Endocrinology · 2013Review
Corrections and comments
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Authors and funding
18 authors at 11 institutions in 9 countries.
Funding
Abstract
Fatty acid composition of adipose tissue changes with weight loss. Palmitoleic acid as a possible marker of endogenous lipogenesis or its functions as a lipokine are under debate. Objective was to assess the predictive role of adipose triglycerides fatty acids in weight maintenance in participants of the DIOGENES dietary intervention study. After an 8-week low calorie diet (LCD) subjects with > 8 % weight loss were randomized to 5 ad libitum weight maintenance diets for 6 months: low protein (P)/low glycemic index (GI) (LP/LGI), low P/high GI (LP/HGI), high P/low GI (HP/LGI), high P/high GI (HP/HGI), and a control diet. Fatty acid composition in adipose tissue triglycerides was determined by gas chromatography in 195 subjects before the LCD (baseline), after LCD and weight maintenance. Weight change after the maintenance phase was positively correlated with baseline adipose palmitoleic (16:1n-7), myristoleic (14:1n-5) and trans-palmitoleic acid (16:1n-7t). Negative correlation was found with baseline oleic acid (18:1n-9). Lower baseline monounsaturated fatty acids (14:1n-5, 16:1n-7 and trans 16:1n-7) in adipose tissue triglycerides predict better weight maintenance. Lower oleic acid predicts lower weight decrease. These findings suggest a specific role of monounsaturated fatty acids in weight management and as weight change predictors.
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Registered trials
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