ArticleInternational journal of vascular medicine2012
The influence of endothelial function and myocardial ischemia on peak oxygen consumption in patients with coronary artery disease.
Article in International journal of vascular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Ischemia Severity, Coronary Artery Disease Extent, and Exercise Capacity in ISCHEMIA.Circulation · 2024Article
- Exercise capacity, cardiac and endothelial function in adults with repaired tetralogy of Fallot.International journal of cardiology. Congenital heart disease · 2022Article
- Effects of Catheterization on Artery Function and Health: When Should Patients Start Exercising Following Their Coronary Intervention?Sports medicine (Auckland, N.Z.) · 2019Review
- Health behaviors and endothelial function.Journal of behavioral medicine · 2008Review
- Exploring Vascular Function Biomarkers: Implications for Rehabilitation.Brazilian journal of cardiovascular surgeryReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Impaired endothelial function has been shown to limit exercise in coronary artery disease (CAD) patients and has been implicated in myocardial ischemia. However, the association of endothelial function and ischemia on peak exercise oxygen consumption (VO(2)) has not been previously reported. A total of 116 CAD patients underwent standard exercise stress testing, during which VO(2) was measured. On a separate day, endothelial-dependent and -independent function were assessed by ultrasound using flow-mediated arterial vasodilation (FMD) and sublingual glyceryl trinitrate administration (GTNMD) of the brachial artery. Patients with exercise-induced myocardial ischemia had lower FMD than nonischemic patients (3.64 ± 0.57 versus 4.98 ± 0.36, P = .050), but there was no difference in GTNMD (14.11 ± 0.99 versus 15.47 ± 0.63, P = .249). Analyses revealed that both FMD (P = .006) and GTNMD (P = .019) were related to peak VO(2). However, neither the presence of ischemia (P = .860) nor the interaction of ischemia with FMD (P = .382) and GTNMD (P = .151) was related to peak VO(2). These data suggest that poor endothelial function, potentially via impaired NO production and smooth muscle dysfunction, may be an important determinant of exercise capacity in patients with CAD, independent of myocardial ischemia.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.