ArticleFrontiers in genetics2012
Molecules affecting hypothalamic control of core body temperature in response to calorie intake.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Promoting health and survival through lowered body temperature.Nature aging · 2025Review
- Transcriptome reveal gene regulation mechanisms of the barnacle Chthamalus challengeri for microhabitat adaption in the intertidal zone.BMC genomics · 2025Article
- Satiety Associated with Calorie Restriction and Time-Restricted Feeding: Central Neuroendocrine Integration.Advances in nutrition (Bethesda, Md.) · 2022Review
- The Hepatic Monocarboxylate Transporter 1 (MCT1) Contributes to the Regulation of Food Anticipation in Mice.Frontiers in physiology · 2021Article
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- Activation of Kappa Opioid Receptor Regulates the Hypothermic Response to Calorie Restriction and Limits Body Weight Loss.Current biology : CB · 2019Article
- Gonadal hormones influence core body temperature during calorie restriction.Temperature (Austin, Tex.) · 2019Article
- Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Changes in ambient temperature elicit divergent control of metabolic and cardiovascular actions by leptin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
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- Deconstructing mammalian thermoregulation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
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- Article
- Role of the hypothalamus in mediating protective effects of dietary restriction during aging.Frontiers in neuroendocrinology · 2013Review
- The role of the nervous system in aging and longevity.Frontiers in genetics · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Core body temperature (CBT) and calorie intake are main components of energy homeostasis and two important regulators of health, longevity, and aging. In homeotherms, CBT can be influenced by calorie intake as food deprivation or calorie restriction (CR) lowers CBT whereas feeding has hyperthermic effects. The finding that in mice CBT prolonged lifespan independently of CR, suggested that the mechanisms modulating CBT may represent important regulators of aging. Here we summarize the current knowledge on the signaling molecules and their receptors that participate in the regulation of CBT responses to calorie intake. These include hypothalamic neuropeptides regulating feeding but also energy expenditure via modulation of thermogenesis. We also report studies indicating that nutrient signals can contribute to regulation of CBT by direct action on hypothalamic preoptic warm-sensitive neurons that in turn regulate adaptive thermogenesis and hence CBT. Finally, we show the role played by two orphans G protein-coupled receptor: GPR50 and GPR83, that were recently demonstrated to regulate temperature-dependent energy expenditure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.