ArticleFrontiers in neurology2012
Antiphospholipid-related chorea.
Article in Frontiers in neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Treatment of Secondary Chorea: A Review of the Current Literature.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Pooled it
- The usefulness of immunotherapy in pediatric neurodegenerative disorders: A systematic review of literature data.Human vaccines & immunotherapeutics · 2015Pooled it
- Diagnostic Challenges in Antiphospholipid Antibody-Associated Chorea: A Case Report.Case reports in neurological medicine · 2025Article
- Dancing with disorder: chorea - an unusual and neglected manifestation of antiphospholipid syndrome.Lupus science & medicine · 2024Article
- Crossed-reflex in antiphospholipid chorea.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Neuropsychiatric Systemic Lupus Erythematosus: Molecules Involved in Its Imunopathogenesis, Clinical Features, and Treatment.Molecules (Basel, Switzerland) · 2024Review
- Chorea as an initial and solitary manifestation of systemic lupus erythematosus with antiphospholipid syndrome in an elderly man.BMJ case reports · 2024Article
- Glucocorticoid reduction induced chorea in pediatric-onset systemic lupus erythematosus: A case report.World journal of clinical cases · 2023Article
- Neurologic Manifestations of Catastrophic Antiphospholipid Syndrome.Current neurology and neuroscience reports · 2022Review
- Antiphospholipid Syndrome Secondary to Lupus Anticoagulant: Case Report for Clinical Anticoagulation Determination.Cureus · 2022Article
- Neurological and Neuropsychiatric Manifestations of Antiphospholipid-Antibody Syndrome (APS).Cureus · 2022Review
- Antiphospholipid-Related Chorea: Two Case Reports and Role of Metabolic Imaging.Movement disorders clinical practice · 2022Review
- Neuropsychiatric Manifestations of Antiphospholipid Syndrome-A Narrative Review.Brain sciences · 2022Review
- Autoimmune and Paraneoplastic Chorea: A Review of the Literature.Frontiers in neurology · 2022Review
- Combined brain/heart magnetic resonance imaging in antiphospholipid syndrome-two sides of the same coin.Clinical rheumatology · 2021Review
- Acute Movement Disorders in Childhood.Journal of clinical medicine · 2021Review
- Neurologic Manifestations of the Antiphospholipid Syndrome - an Update.Current neurology and neuroscience reports · 2021Review
- Non-Criteria Manifestations of Juvenile Antiphospholipid Syndrome.Journal of clinical medicine · 2021Review
- Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies.Brain sciences · 2020Article
- Antiphospholipid syndrome: A diagnostic challenge.Medical journal, Armed Forces India · 2016Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chorea is a movement disorder which may be associated with immunologic diseases, in particular in the presence of antiphospholipid antibodies (aPL). Choreic movements have been linked to the isolated presence of plasmatic aPL, or to primary, or secondary antiphospholipid syndrome. The highest incidence of aPL-related chorea is detected in children and females. The presentation of chorea is usually subacute and the course monophasic. Choreic movements can be focal, unilateral, or generalized. High plasmatic titers of aPL in a choreic patient can suggest the diagnosis of aPL-related chorea; neuroimaging investigation does not provide much additional diagnostic information. The most relevant target of aPL is β2-glycoprotein I, probably responsible for the thrombotic manifestations of antiphospholipid syndrome. Etiology of the movement disorder is not well understood but a neurotoxic effect of aPL has been hypothesized, leading to impaired basal ganglia cell function and development of neuroinflammation. Patients affected by aPL-related chorea have an increased risk of thrombosis and should receive antiplatelet or anticoagulant treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.