ArticleMolecular biology of the cell2012
Tor1 regulates protein solubility in Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Methionine Sulfoxide Reductases Suppress the Formation of the [Antioxidants (Basel, Switzerland) · 2023Article
- Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast.Oncotarget · 2022Article
- Extensive accumulation of misfolded protein aggregates during natural aging and senescence.Frontiers in aging neuroscience · 2022Article
- Role ofInternational journal of molecular sciences · 2021Article
- Arsenic Exposure and Compromised Protein Quality Control.Chemical research in toxicology · 2020Review
- Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.International journal of molecular sciences · 2020Review
- Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging ineLife · 2019Article
- Loss of mRNA surveillance pathways results in widespread protein aggregation.Scientific reports · 2018Article
- Article
- Restricted access: spatial sequestration of damaged proteins during stress and aging.EMBO reports · 2017Review
- Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation.Frontiers in aging neuroscience · 2017Article
- Role of Proteome Physical Chemistry in Cell Behavior.The journal of physical chemistry. B · 2016Review
- Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans.Cell metabolism · 2016Article
- Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans.G3 (Bethesda, Md.) · 2016Article
- Distinct stress conditions result in aggregation of proteins with similar properties.Scientific reports · 2016Article
- Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan.Cell cycle (Georgetown, Tex.) · 2014Review
- Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress.Nature cell biology · 2013Article
- Role of protein misfolding and proteostasis deficiency in protein misfolding diseases and aging.International journal of cell biology · 2013Review
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Authors and funding
9 authors.
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Abstract
Accumulation of insoluble protein in cells is associated with aging and aging-related diseases; however, the roles of insoluble protein in these processes are uncertain. The nature and impact of changes to protein solubility during normal aging are less well understood. Using quantitative mass spectrometry, we identify 480 proteins that become insoluble during postmitotic aging in Saccharomyces cerevisiae and show that this ensemble of insoluble proteins is similar to those that accumulate in aging nematodes. SDS-insoluble protein is present exclusively in a nonquiescent subpopulation of postmitotic cells, indicating an asymmetrical distribution of this protein. In addition, we show that nitrogen starvation of young cells is sufficient to cause accumulation of a similar group of insoluble proteins. Although many of the insoluble proteins identified are known to be autophagic substrates, induction of macroautophagy is not required for insoluble protein formation. However, genetic or chemical inhibition of the Tor1 kinase is sufficient to promote accumulation of insoluble protein. We conclude that target of rapamycin complex 1 regulates accumulation of insoluble proteins via mechanisms acting upstream of macroautophagy. Our data indicate that the accumulation of proteins in an SDS-insoluble state in postmitotic cells represents a novel autophagic cargo preparation process that is regulated by the Tor1 kinase.
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