ArticleJournal of virology2013
Influenza A viruses grow in human pancreatic cells and cause pancreatitis and diabetes in an animal model.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
- Incidence of diabetes mellitus following hospitalisation with influenza: a population-based cohort study in England.BMJ open · 2026Article
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- Identification and verification of inflammatory biomarkers for primary Sjögren's syndrome.Clinical rheumatology · 2024Article
- Acute hemorrhagic pancreatitis following influenza infection: a case report.Journal of medical case reports · 2023Article
- Identification of Heterophilic Epitopes of H1N1 Influenza Virus Hemagglutinin.Current microbiology · 2023Article
- The distribution of heterophilic antigens and their relationship with autoimmune diseases.Frontiers in immunology · 2023Article
- Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity.Pathogens (Basel, Switzerland) · 2022Article
- Microbial (co)infections: Powerful immune influencers.PLoS pathogens · 2022Review
- Dysglycemia after COVID-19 pneumonia: a six-month cohort study.Acta diabetologica · 2021Article
- Association between influenza and the incidence rate of new-onset type 1 diabetes in Japan.Journal of diabetes investigation · 2021Article
- An Integrative Network Approach to Identify Common Genes for the Therapeutics in Tuberculosis and Its Overlapping Non-Communicable Diseases.Frontiers in pharmacology · 2021Article
- Review
- Suspected case of COVID-19-associated pancreatitis in a child.Radiology case reports · 2020Article
- Genetic Susceptibility of the Host in Virus-Induced Diabetes.Microorganisms · 2020Review
- Potential of H1N1 influenza A virus as an air borne pathogen to induce infectivity in pancreas: a mouse model study.Journal of environmental health science & engineering · 2020Article
- Silent Infection of B and CD8Journal of virology · 2020Article
- Acute Pancreatitis Caused by Complications of Influenza A in the Setting of Chronic Lymphocytic Leukemia.Cureus · 2020Article
- Human herpesvirus-6 is present at higher levels in the pancreatic tissues of donors with type 1 diabetes.Journal of autoimmunity · 2020Article
- Abdominal and Pelvic Organ Failure Induced by Intraperitoneal Influenza A Virus Infection in Mice.Frontiers in microbiology · 2020Article
- Innate Immunity Mediated Inflammation and Beta Cell Function: Neighbors or Enemies?Frontiers in endocrinology · 2020Review
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza A viruses commonly cause pancreatitis in naturally and experimentally infected animals. In this study, we report the results of in vivo investigations carried out to establish whether influenza virus infection could cause metabolic disorders linked to pancreatic infection. In addition, in vitro tests in human pancreatic islets and in human pancreatic cell lines were performed to evaluate viral growth and cell damage. Infection of an avian model with two low-pathogenicity avian influenza isolates caused pancreatic damage resulting in hyperlipasemia in over 50% of subjects, which evolved into hyperglycemia and subsequently diabetes. Histopathology of the pancreas showed signs of an acute infection resulting in severe fibrosis and disruption of the structure of the organ. Influenza virus nucleoprotein was detected by immunohistochemistry (IHC) in the acinar tissue. Human seasonal H1N1 and H3N2 viruses and avian H7N1 and H7N3 influenza virus isolates were able to infect a selection of human pancreatic cell lines. Human viruses were also shown to be able to infect human pancreatic islets. In situ hybridization assays indicated that viral nucleoprotein could be detected in beta cells. The cytokine activation profile indicated a significant increase of MIG/CXCL9, IP-10/CXCL10, RANTES/CCL5, MIP1b/CCL4, Groa/CXCL1, interleukin 8 (IL-8)/CXCL8, tumor necrosis factor alpha (TNF-α), and IL-6. Our findings indicate that influenza virus infection may play a role as a causative agent of pancreatitis and diabetes in humans and other mammals.
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