ArticleAutism research : official journal of the International Society for Autism Research2012
Autism risk gene MET variation and cortical thickness in typically developing children and adolescents.
Article in Autism research : official journal of the International Society for Autism Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- The subcortical correlates of autistic traits in school-age children: a population-based neuroimaging study.Molecular autism · 2023Article
- Maternal autoimmune disease and risk of offspring autism spectrum disorder - a nationwide population-based cohort study.Frontiers in psychiatry · 2023Article
- Structural neuroimaging phenotypes and associated molecular and genomic underpinnings in autism: a review.Frontiers in neuroscience · 2023Review
- Genetics of structural and functional brain changes in autism spectrum disorder.Translational psychiatry · 2020Review
- Structural neuroimaging correlates of social deficits are similar in autism spectrum disorder and attention-deficit/hyperactivity disorder: analysis from the POND Network.Translational psychiatry · 2019Article
- Developmental Connectivity and Molecular Phenotypes of Unique Cortical Projection Neurons that Express a Synapse-Associated Receptor Tyrosine Kinase.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2018Article
- HLA-class II haplotypes and Autism Spectrum Disorders.Scientific reports · 2018Article
- Differential impact ofNeurobiology of stress · 2018Article
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- The Pleiotropic MET Receptor Network: Circuit Development and the Neural-Medical Interface of Autism.Biological psychiatry · 2017Review
- Distinct intracellular signaling mediates C-MET regulation of dendritic growth and synaptogenesis.Developmental neurobiology · 2016Article
- Preliminary evidence for association of genetic variants in pri-miR-34b/c and abnormal miR-34c expression with attention deficit and hyperactivity disorder.Translational psychiatry · 2016Article
- Insulin-Independent GABAA Receptor-Mediated Response in the Barrel Cortex of Mice with Impaired Met Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder.Progress in neurobiology · 2015Review
- Are Autistic Traits in the General Population Related to Global and Regional Brain Differences?Journal of autism and developmental disorders · 2015Article
- Immune mediators in the brain and peripheral tissues in autism spectrum disorder.Nature reviews. Neuroscience · 2015Review
- Complete or partial reduction of the Met receptor tyrosine kinase in distinct circuits differentially impacts mouse behavior.Journal of neurodevelopmental disorders · 2015Article
- Neural signatures of autism spectrum disorders: insights into brain network dynamics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
MET receptor tyrosine kinase (MET) has been proposed as a candidate risk gene for autism spectrum disorder (ASD) based on associations between MET polymorphisms and ASD diagnosis, as well as evidence from animal studies that MET protein may regulate early development of cortical regions implicated in the neurobiology of ASD. The relevance of differences in MET signaling for human cortical development remains unexamined, however. We sought to address this issue by relating genotype at a functional single nucleotide polymorphism within the MET promoter (rs1858830, G→C) to in vivo measures of cortical thickness (CT) development derived from 222 healthy children and adolescents with 514 longitudinally acquired structural magnetic resonance imaging brain scans between ages 9 and 22 years. We identified a statistically significant, developmentally fixed, and stepwise CT reduction with increasing C allele dose in superior and middle temporal gyri, ventral precentral and postcentral gyri, and anterior cingulate bilaterally, and in the right frontopolar cortex. We were also able to demonstrate that mean CT within these cortical regions showed a statistically significant reduction with increasing scores on a continuous measure of autistic traits (the Social Responsiveness Scale). The cortical regions highlighted by our analyses are not only established areas of MET expression during prenatal life but are also key components of the "social brain" that have frequently shown structural and functional abnormalities in autism. Our results suggest that genetic differences in the MET gene may influence the development of cortical systems implicated in the neurobiology of ASD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.