ArticleHuman brain mapping2014
The human amygdala and pain: evidence from neuroimaging.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
146 citing papers in PubMed, 5 syntheses or guidelines pooled it, 252 citations in OpenAlex.
- Altered spontaneous brain activity in lumbar disc herniation patients: insights from an ALE meta-analysis of neuroimaging data.Frontiers in neuroscience · 2024Pooled it
- The medial temporal lobe in nociception: a meta-analytic and functional connectivity study.Pain · 2019Pooled it
- A meta-analytic study of experimental and chronic orofacial pain excluding headache disorders.NeuroImage. Clinical · 2018Pooled it
- Functional reorganisation in chronic pain and neural correlates of pain sensitisation: A coordinate based meta-analysis of 266 cutaneous pain fMRI studies.Neuroscience and biobehavioral reviews · 2016Pooled it
- Coordinate-based (ALE) meta-analysis of brain activation in patients with fibromyalgia.Human brain mapping · 2016Pooled it
- Reconsolidation Blockade with Propranolol as a Novel Treatment for Chronic Low-Back Pain: A Double-Blind Randomized Placebo-Controlled Feasibility Study.Journal of pain research · 2026Trial
- Effects of oxytocin administration and conditioned oxytocin on brain activity: An fMRI study.PloS one · 2020Trial
- Review
- Exploring central sensitization symptoms in children with ADHD and their parents: a case-control study.BMC psychiatry · 2026Article
- Article
- Elevated TRPV1 expression in the central nucleus of the amygdala participates in initial pain and subsequent anxiety-related behaviors in mice undergoing orthodontic tooth movement.BMC oral health · 2026Article
- Amygdala and nucleus accumbens activation are associated with treatment choice in knee osteoarthritis: an fMRI study.Arthroplasty (London, England) · 2026Article
- Frequency of bullying modulates amygdala response during social exclusion in participants with non-suicidal self-injury.European child & adolescent psychiatry · 2026Article
- Molecular Signatures of Maladaptive Plasticity in the Amygdala in a Rat Model of Chronic Neuropathic Pain.Cells · 2026Article
- Prelimbic cortex-basolateral amygdala glutamatergic circuit drives cancer-induced bone pain in mice.iScience · 2026Article
- Chronic stress increases the susceptibility to chronic vulvar pain following acute vulvar inflammation in a preclinical model of vulvodynia.Molecular brain · 2026Article
- Perceived Maternal Overprotection and Amygdala Functional Connectivity in Children: Implications for Childhood Depressive Symptoms.Depression and anxiety · 2026Article
- Precision connectivity in osteoarthritis pain with permutation and network analysis: a key step toward clinical application.BMC medical imaging · 2025Article
- Reduced volume in the amygdala of trigeminal neuralgia patients: a neuroimaging study with clinical correlates.Experimental brain research · 2025Article
- Fibromyalgia in the Era of Brain PET/CT Imaging.Journal of clinical medicine · 2025Review
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The amygdala, a small deep brain structure involved in behavioral processing through interactions with other brain regions, has garnered increased attention in recent years in relation to pain processing. As pain is a multidimensional experience that encompasses physical sensation, affect, and cognition, the amygdala is well suited to play a part in this process. Multiple neuroimaging studies of pain in humans have reported activation in the amygdala. Here, we summarize these studies by performing a coordinate-based meta-analysis within experimentally induced and clinical pain studies using an activation likelihood estimate analysis. The results are presented in relation to locations of peak activation within and outside of amygdala subregions. The majority of studies identified coordinates consistent with human amygdala cytoarchitecture indicating reproducibility in neuroanatomical labeling across labs, analysis methods, and imaging modalities. Differences were noted between healthy and clinical pain studies: in clinical pain studies, peak activation was located in the laterobasal region, suggestive of the cognitive-affective overlay present among individuals suffering from chronic pain; while the less understood superficial region of the amygdala was prominent among experimental pain studies. Taken together, these findings suggest several important directions for further research exploring the amygdala's role in pain processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.