ArticleThe American journal of clinical nutrition2012
Novel circulating fatty acid patterns and risk of cardiovascular disease: the Cardiovascular Health Study.
Article in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of Mediterranean Diet or Low-Fat Diet on Blood Fatty Acids in Patients with Coronary Heart Disease. A Randomized Intervention Study.Nutrients · 2021Trial
- Lipoprotein-Specific Fatty Acid Profiles in Familial Hypercholesterolemia: Associations with Cardiovascular History and Dietary Patterns.Nutrients · 2025Article
- Free fatty acids and mortality among adults in the United States: a report from US National Health and Nutrition Examination Survey (NHANES).Nutrition & metabolism · 2024Article
- Association between Dietary Fatty Acid Patterns and Colorectal Cancer Risk: A Large-Scale Case-Control Study in China.Nutrients · 2022Article
- Associations of Plasma Fatty Acid Patterns During Pregnancy With Gestational Diabetes Mellitus.Frontiers in nutrition · 2022Article
- Serum Nonesterified Fatty Acids and Incident Stroke: The CHS.Journal of the American Heart Association · 2021Article
- Associations of Serum Nonesterified Fatty Acids With Coronary Heart Disease Mortality and Nonfatal Myocardial Infarction: The CHS (Cardiovascular Health Study) Cohort.Journal of the American Heart Association · 2021Article
- Associations of plasma total phospholipid fatty acid patterns with feeding practices, growth, and psychomotor development in 6-month-old South African infants.Maternal & child nutrition · 2019Article
- Blood Fatty Acid Profiles: New Biomarkers for Cardiometabolic Disease Risk.Current atherosclerosis reports · 2018Review
- A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study.PLoS medicine · 2017Article
- Hospital Admissions for Myocardial Infarction and Stroke Before and After the Trans-Fatty Acid Restrictions in New York.JAMA cardiology · 2017Observational
- Associations of erythrocyte fatty acid patterns with insulin resistance.The American journal of clinical nutrition · 2016Article
- The FAT expandability (FATe) Project: Biomarkers to determine the limit of expansion and the complications of obesity.Cardiovascular diabetology · 2015Article
- Dietary trans fatty acids and cardiovascular disease risk: past and present.Current atherosclerosis reports · 2014Review
- Intake of trans fat and incidence of stroke in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.The American journal of clinical nutrition · 2014Article
- Ethnic- and sex-specific associations between plasma fatty acids and markers of insulin resistance in healthy young adults.Nutrition & metabolism · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundComplex interplays of diet and metabolism influence circulating fatty acids (FAs), possibly constituting FA patterns related to cardiovascular disease (CVD) risk.
objectivesWe aimed to derive FA patterns from circulating FAs, relate the patterns to CVD incidence, and extend the derived patterns to atherosclerosis progression in another independent cohort.
designWe used principal component analysis (PCA) to derive FA patterns from 38 plasma phospholipid FAs in 2972 older adults in the Cardiovascular Health Study (CHS). Identified patterns were evaluated for prospective associations with 14-y incidence of CVD [ischemic heart disease (IHD) or stroke]. In another independent cohort of postmenopausal women with IHD, we evaluated associations of the CHS-derived patterns with 3.2-y progression of angiographically defined coronary atherosclerosis.
resultsThree distinct patterns were identified, characterized by higher proportions of trans FAs, de novo lipogenesis (DNL) FAs, and long-chain MUFAs (LCMUFAs). During 32,265 person-years, 780 incident CVD events occurred. The trans FA pattern was associated with higher CVD risk (multivariable-adjusted HR for the highest compared with the lowest quintiles = 1.58; 95% CI: 1.17, 2.12; P-trend = 0.006), primarily attributable to higher risk of stroke (HR: 2.46; 95% CI: 1.54, 3.92; P-trend = 0.005). The DNL and LCMUFA patterns were not associated with CVD incidence or with IHD or stroke (P-trend > 0.11 each). In the second cohort, the trans FA pattern, but not the other 2 patterns, was positively associated with progression of coronary atherosclerosis (P-trend < 0.05).
conclusionsPCA appears to provide informative circulating FA patterns. A pattern driven mainly by trans FA levels related to greater CVD risk in older adults and coronary atherosclerosis progression in women with IHD.
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