SynthesisAmerican journal of epidemiology2012
Soy food intake and risk of lung cancer: evidence from the Shanghai Women's Health Study and a meta-analysis.
Synthesis in American journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Soy Product Consumption and the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies.Nutrients · 2024Pooled it
- Intake of Soy, Soy Isoflavones and Soy Protein and Risk of Cancer Incidence and Mortality.Frontiers in nutrition · 2022Pooled it
- Soy food consumption and lung cancer risk: a meta-analysis using a common measure across studies.Nutrition and cancer · 2013Pooled it
- Dietary risk factors for lung cancer: an umbrella review of systematic review and meta-analysis.Translational cancer research · 2026Review
- The association between plant protein intake and cancer risk: a prospective cohort study.Nutrition journal · 2026Article
- Saponins in soy reduce NNK-induced lung cancer by increasing plasma isoflavone levels.Scientific reports · 2025Article
- HSA Adductomics in the Shanghai Women's Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism.Antioxidants (Basel, Switzerland) · 2025Article
- Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study.Journal of epidemiology · 2023Article
- Calcium Intake and Lung Cancer Risk: A Pooled Analysis of 12 Prospective Cohort Studies.The Journal of nutrition · 2023Article
- Phytoestrogens and lung cancer risk: a nested case-control study in never-smoking Chinese women.The American journal of clinical nutrition · 2022Article
- Microarray analysis of differentially expressed long non-coding RNAs in daidzein-treated lung cancer cells.Oncology letters · 2021Article
- Menstrual factors, reproductive history, and risk of lung cancer: a multi-center population-based cohort study in Chinese females.Translational lung cancer research · 2021Article
- Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China.JAMA network open · 2019Article
- Drug Resistance in Non-Small Cell Lung Cancer: A Potential for NOTCH Targeting?Frontiers in oncology · 2018Review
- Secular trend analysis of lung cancer incidence in Sihui city, China between 1987 and 2011.Chinese journal of cancer · 2015Article
- Prediagnosis soy food consumption and lung cancer survival in women.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Article
- Habitual consumption of soy products and risk of nasopharyngeal carcinoma in Chinese adults: a case-control study.PloS one · 2013Article
- Calcium intake and lung cancer risk among female nonsmokers: a report from the Shanghai Women's Health Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Dietary B vitamin and methionine intakes and lung cancer risk among female never smokers in China.Cancer causes & control : CCC · 2012Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The authors prospectively evaluated the association of soy food intake with lung cancer risk, overall and by tumor aggressiveness, and performed a meta-analysis of published data. Included in the analysis were 71,550 women recruited into the Shanghai Women's Health Study (Shanghai, China) in 1997-2000. Usual soy food intake was assessed at baseline and reassessed during follow-up through in-person interviews. During a mean follow-up period of 9.1 years, 370 incident lung cancer cases were identified; 340 patients were lifetime never smokers. After adjustment for potential confounders, soy food intake was inversely associated with subsequent risk of lung cancer (P(trend) = 0.004); the hazard ratio for the highest quintile of intake compared with the lowest was 0.63 (95% confidence interval: 0.44, 0.90). This inverse association appeared predominately among women with later age at menopause (P(interaction) = 0.01) and for aggressive lung cancer as defined by length of survival (<12 months vs. ≥12 months; P(heterogeneity) = 0.057). Meta-analysis of 7 studies conducted among nonsmokers found a summary relative risk of 0.59 (95% confidence interval: 0.49, 0.71) for the highest categories of soy or isoflavone intake versus the lowest. This study suggests that soy food consumption may reduce lung cancer risk in nonsmoking women, particularly for aggressive tumors, and its effect may be modified by endogenous estrogens.
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