ArticleJournal of cell science2013
Axonal transport of neural membrane protein 35 mRNA increases axon growth.
Article in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed.
- Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2.Cell genomics · 2024Article
- Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR ofbioRxiv : the preprint server for biology · 2023Article
- Endoplasmic Reticulum in Metaplasticity: From Information Processing to Synaptic Proteostasis.Molecular neurobiology · 2022Review
- Axonal mRNA localization and translation: local events with broad roles.Cellular and molecular life sciences : CMLS · 2021Review
- Inhibition ofAging · 2020Article
- Mechanism and role of the intra-axonal Calreticulin translation in response to axonal injury.Experimental neurology · 2020Article
- Ion and pH Sensitivity of a TMBIM CaStructure (London, England : 1993) · 2019Article
- Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- To the end of the line: Axonal mRNA transport and local translation in health and neurodegenerative disease.Developmental neurobiology · 2018Review
- Analysis of piRNA-Like Small Non-coding RNAs Present in Axons of Adult Sensory Neurons.Molecular neurobiology · 2018Article
- TMBIM-mediated CaBiochimica et biophysica acta. Molecular cell research · 2017Review
- Molecular determinants of cytochrome C oxidase IV mRNA axonal trafficking.Molecular and cellular neurosciences · 2017Article
- There and back again: coordinated transcription, translation and transport in axonal survival and regeneration.Current opinion in neurobiology · 2016Review
- Local translation of cell adhesion molecules in axons.Neural regeneration research · 2016Article
- Whole transcriptome profiling reveals the RNA content of motor axons.Nucleic acids research · 2016Article
- Exercise dependent increase in axon regeneration into peripheral nerve grafts by propriospinal but not sensory neurons after spinal cord injury is associated with modulation of regeneration-associated genes.Experimental neurology · 2016Article
- Isolation and analyses of axonal ribonucleoprotein complexes.Methods in cell biology · 2016Article
- Filamin A is required in injured axons for HDAC5 activity and axon regeneration.The Journal of biological chemistry · 2015Article
- mRNAs and Protein Synthetic Machinery Localize into Regenerating Spinal Cord Axons When They Are Provided a Substrate That Supports Growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Many neuronal mRNAs are transported from cell bodies into axons and dendrites. Localized translation of the mRNAs brings autonomy to these processes that can be vast distances from the cell body. For axons, these translational responses have been linked to growth and injury signaling, but there has been little information about local function of individual axonally synthesized proteins. In the present study, we show that axonal injury increases levels of the mRNA encoding neural membrane protein 35 (NMP35) in axons, with a commensurate decrease in the cell body levels of NMP35 mRNA. The 3' untranslated region (3'UTR) of NMP35 is responsible for this localization into axons. Previous studies have shown that NMP35 protein supports cell survival by inhibiting Fas-ligand-mediated apoptosis; however, these investigations did not distinguish functions of the locally generated NMP35 protein. Using axonally targeted versus cell-body-restricted NMP35 constructs, we show that NMP35 supports axonal growth, and overexpression of an axonally targeted NMP35 mRNA is sufficient to increase axonal outgrowth.
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