ReviewPflugers Archiv : European journal of physiology2013
Renal renin secretion as regulator of body fluid homeostasis.
Review in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Effect of volume expansion with hypertonic- and isotonic saline and isotonic glucose on sodium and water transport in the principal cells in the kidney.BMC nephrology · 2013Trial
- Correlation of absolute nil-per-oral status with inferior vena cava collapsibility index and post-spinal hypotension in infra-umbilical surgeries: An observational study.Indian journal of anaesthesia · 2026Article
- Artificial and natural selection components reveal the mechanisms of tropical sheep populations against gastrointestinal parasites.PloS one · 2026Article
- Sodium disrupts mitochondrial energy metabolism to execute NECSO.Nature communications · 2025Article
- The Contribution of the Renin-Angiotensin System to Alzheimer's Disease.Current topics in behavioral neurosciences · 2025Review
- Kidney Renin Release under Hypoxia and Its Potential Link with Nitric Oxide: A Narrative Review.Biomedicines · 2023Review
- Effects of Different Dietary Protein Level on Growth Performance, Rumen Fermentation Characteristics and Plasma Metabolomics Profile of Growing Yak in the Cold Season.Animals : an open access journal from MDPI · 2023Article
- A New Perspective on the Renin-Angiotensin System.Diagnostics (Basel, Switzerland) · 2022Review
- Mechanism of herbal medicine on hypertensive nephropathy (Review).Molecular medicine reports · 2021Review
- A simple high throughput assay to evaluate water consumption in the fruit fly.Scientific reports · 2017Article
- Understanding and preventing contrast-induced acute kidney injury.Nature reviews. Nephrology · 2017Review
- Dietary salt regulates uroguanylin expression and signaling activity in the kidney, but not in the intestine.Physiological reports · 2016Article
- Salt feedback on the renin-angiotensin-aldosterone system.Pflugers Archiv : European journal of physiology · 2015Review
- Circulatory responses to lower body negative pressure in young Afghans and Danes: implications for understanding ethnic effects on blood pressure regulation.European journal of applied physiology · 2014Article
- Regulation of renin secretion and arterial pressure during prolonged baroreflex activation: influence of salt intake.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Dominant factors that govern pressure natriuresis in diuresis and antidiuresis: a mathematical model.American journal of physiology. Renal physiology · 2014Article
- SGLT-2 inhibitors and their potential in the treatment of diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2013 · on this mapReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The renin-angiotensin system is essential for body fluid homeostasis and blood pressure regulation. This review focuses on the homeostatic regulation of the secretion of active renin in the kidney, primarily in humans. Under physiological conditions, renin secretion is determined mainly by sodium intake, but the specific pathways involved and the relations between them are not well defined. In animals, renin secretion is a log-linear function of sodium intake. Close associations exist between sodium intake, total body sodium, extracellular fluid volume, and blood volume. Plasma volume increases by about 1.5 mL/mmol increase in daily sodium intake. Several lines of evidence indicate that central blood volume may vary substantially without measurable changes in arterial blood pressure. At least five intertwining feedback loops of renin regulation are identifiable based on controlled variables (blood volume, arterial blood pressure), efferent pathways to the kidney (nervous, humoral), and pathways operating via the macula densa. Taken together, the available evidence favors the notion that under physiological conditions (1) volume-mediated regulation of renin secretion is the primary regulator, (2) macula densa mediated mechanisms play a substantial role as co-mediator although the controlled variables are not well defined so far, and (3) regulation via arterial blood pressure is the exception rather than the rule. Improved quantitative analyses based on in vivo and in silico models are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.