ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2013
Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Association between ladybird homeobox 1 gene polymorphisms and adolescent idiopathic scoliosis: A MOOSE-compliant meta-analysis.Medicine · 2019Pooled it
- Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects.BMC musculoskeletal disorders · 2016Pooled it
- Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.Nature genetics · 2013Pooled it
- Article
- The importance of imperfect pre-clinical models in adolescent idiopathic scoliosis.Disease models & mechanisms · 2025Review
- Role ofNarra J · 2025Article
- Genetics and pathogenesis of scoliosis.North American Spine Society journal · 2024Article
- The Role of Muscle Biomarkers in Adolescent Idiopathic Scoliosis.Journal of clinical medicine · 2023Review
- Genetic animal modeling for idiopathic scoliosis research: history and considerations.Spine deformity · 2022Review
- Genetic variants associated with the occurrence and progression of adolescent idiopathic scoliosis: a systematic review protocol.Systematic reviews · 2022Article
- Epigenetic and Genetic Factors Related to Curve Progression in Adolescent Idiopathic Scoliosis: A Systematic Scoping Review of the Current Literature.International journal of molecular sciences · 2022Article
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- Article
- A Functional SNP in the Promoter ofFrontiers in cell and developmental biology · 2021Article
- The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic Scoliosis.Frontiers in genetics · 2020Review
- Genetic Variations of Ultraconserved Elements in the Human Genome.Omics : a journal of integrative biology · 2019Article
- Positive association between a polymorphic locus near the LBX1 gene and predisposition of idiopathic scoliosis in Southeastern European population.Journal of applied biomedicine · 2019Article
- Idiopathic Scoliosis Families Highlight Actin-Based and Microtubule-Based Cellular Projections and Extracellular Matrix in Disease Etiology.G3 (Bethesda, Md.) · 2018Article
- Identification of Elongated Primary Cilia with Impaired Mechanotransduction in Idiopathic Scoliosis Patients.Scientific reports · 2017Article
- Spinal growth velocity versus height velocity in predicting curve progression in peri-pubertal girls with idiopathic scoliosis.BMC musculoskeletal disorders · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate whether rs11190870 near LBX1 correlates with the susceptibility or curve progression of adolescent idiopathic scoliosis (AIS) in a Han Chinese population.
methodsA total of 949 AIS patients and 976 age-matched healthy controls were recruited. All the subjects were genotyped using the PCR-based invader assay. Case-control study and case-only study were performed to define the contribution of rs11190870 to predisposition and curve severity of AIS. Additionally, we further conducted a meta-analysis of the study findings together with those of previously reported studies.
resultsA significant association of rs11190870 with AIS was observed in the Han Chinese population (P = 1.8 × 10(-9); odd ratio = 1.51; 95 % confidence interval = 1.33-1.71), and AIS patients with TT genotype had a larger Cobb angle than those with TC or CC genotype (P = 0.005). The meta-analysis confirmed that the positive association of this SNP with AIS in the East Asian population.
conclusionsThe SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of AIS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.