ArticleDiabetologia2013
Worse glycaemic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy.
Article in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Islet autoantibody positivity in overweight and obese adults with type 2 diabetes.Autoimmunity · 2018Trial
- Increased cardiovascular risk in people with LADA in comparison to type 1 diabetes and type 2 diabetes: Findings from the DPV registry in Germany and Austria.Diabetes, obesity & metabolism · 2025Article
- Article
- Pathology of Diabetes-Induced Immune Dysfunction.International journal of molecular sciences · 2024Review
- Adult-onset autoimmune diabetes.Nature reviews. Disease primers · 2022Review
- Latent autoimmune diabetes in adults in China.Frontiers in immunology · 2022Review
- Adult-Onset Type 1 Diabetes: Current Understanding and Challenges.Diabetes care · 2021Review
- Low rate of latent autoimmune diabetes in adults (LADA) in patients followed for type 2 diabetes: A single center's experience in Turkey.Archives of endocrinology and metabolism · 2021Article
- Latent Autoimmune Diabetes in Adults (LADA) and its Metabolic Characteristics among Yemeni Type 2 Diabetes Mellitus Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Oxidative Stress and Its Related Factors in Latent Autoimmune Diabetes in Adults.BioMed research international · 2021Article
- Geographic location determines beta-cell autoimmunity among adult Ghanaians: Findings from the RODAM study.Immunity, inflammation and disease · 2020Article
- Uncommon Presentations of Diabetes: Zebras in the Herd.Clinical diabetes : a publication of the American Diabetes Association · 2020Article
- Urinary C-Peptide Creatinine Ratio as a Non-Invasive Tool for Identifying Latent Autoimmune Diabetes in Adults (LADA).Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Islet Cell Associated Autoantibodies and C-Peptide Levels in Patients with Diabetes and Symptoms of Gastroparesis.Frontiers in endocrinology · 2018Article
- Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes.Cardiovascular diabetology · 2017Article
- Should There be Concern About Autoimmune Diabetes in Adults? Current Evidence and Controversies.Current diabetes reports · 2016Review
- Article
- Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment.Diabetologia · 2016Review
- Geospatial analysis of food environment demonstrates associations with gestational diabetes.American journal of obstetrics and gynecology · 2016Article
- Latent autoimmune diabetes of the adult: current knowledge and uncertainty.Diabetic medicine : a journal of the British Diabetic Association · 2015Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisOur aim was to study whether glycaemic control differs between individuals with latent autoimmune diabetes in adults (LADA) and patients with type 2 diabetes, and whether it is influenced by time on insulin therapy.
methodsWe performed a retrospective study of 372 patients with LADA (205 men and 167 women; median age 54 years, range 35-80 years) from Swedish cohorts from Skåne (n = 272) and Västerbotten (n = 100). Age- and sex-matched patients with type 2 diabetes were included as controls. Data on the use of oral hypoglycaemic agents (OHAs), insulin and insulin-OHA combination therapy was retrieved from the medical records. Poor glycaemic control was defined as HbA(1c) ≥7.0% (≥53 mmol/mol) at follow-up.
resultsThe individuals with LADA and with type 2 diabetes were followed for an average of 107 months. LADA patients were leaner than type 2 diabetes patients at diagnosis (BMI 27.7 vs 31.0 kg/m(2); p < 0.001) and follow-up (BMI 27.9 vs 30.2 kg/m(2); p < 0.001). Patients with LADA had been treated with insulin for longer than those with type 2 diabetes (53.3 vs 28.8 months; p < 0.001). There was no significant difference between the patient groups with regard to poor glycaemic control at diagnosis, but more patients with LADA (67.8%) than type 2 diabetes patients (53.0%; p < 0.001) had poor glycaemic control at follow-up. Patients with LADA had worse glycaemic control at follow-up compared with participants with type 2 diabetes (OR = 1.8, 95% CI 1.2, 2.7), adjusted for age at diagnosis, HbA(1c), BMI at diagnosis, follow-up time and duration of insulin treatment. CONCLUSIONS/
interpretationIndividuals with LADA have worse glycaemic control than patients with type 2 diabetes despite a longer time on insulin therapy.
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