ArticlePediatric research2013
Caffeine improves the ability of serotonin-deficient (Pet-1-/-) mice to survive episodic asphyxia.
Article in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Reducing the risk of sudden unexpected infant death: the caffeine hypothesis.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Effect of adenosinergic manipulations on amygdala-kindled seizures in mice: Implications for sudden unexpected death in epilepsy.Epilepsia · 2024Article
- The microbiome is dispensable for normal respiratory function and chemoreflexes in mice.Frontiers in physiology · 2024Article
- The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome.Journal of neuropathology and experimental neurology · 2019Review
- Acute perturbation ofeLife · 2018Article
- A low cost, simplified, and scaleable pneumotachograph and face mask for neonatal mouse respiratory measurements.Journal of pharmacological and toxicological methods · 2017Article
- Interactive effects of maternal cigarette smoke, heat stress, hypoxia, and lipopolysaccharide on neonatal cardiorespiratory and cytokine responses.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Sudden Unexpected Death in Fetal Life Through Early Childhood.Pediatrics · 2016Article
- Adenosine A1-receptor blockade impairs the ability of rat pups to autoresuscitate from primary apnea during repeated exposure to hypoxia.Physiological reports · 2015Article
- Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase.International journal of molecular sciences · 2013Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIn neonatal rodents, serotonin (5-HT) neurons are critical for successful autoresuscitation. We hypothesized that caffeine, a respiratory stimulant, would hasten the onset of gasping and improve autoresuscitation in 5-HT-deficient, Pet-1(-/-) mice.
methodsUsing a head-out system and electrocardiogram, we measured respiratory and heart rate (HR) responses of Pet-1(-/-) rodents and their littermates during episodic asphyxia at postnatal days 8-9 (P8-9). After a baseline recording, we injected either vehicle or caffeine (i.p.) at doses of 1, 5, or 10 mg/kg. We then induced 10 brief (~30 s) episodes of asphyxia, each interspersed with 5 min of room air to allow autoresuscitation. In addition to measuring survival, we measured the duration of hypoxic apnea (time to initiate gasping) and time to recover eupnea and HR.
resultsCaffeine had a dose-dependent effect of hastening the onset of gasping, recovery of breathing, and restoration of HR in Pet-1(-/-) (but not in wild-type) rodents, thereby improving survival across asphyxic episodes. Increased survival was strongly correlated with hastened onset of gasping.
conclusionOur data suggest that caffeine reduces mortality relating to asphyxia and 5-HT deficiency. These findings may be relevant for efforts to reduce the incidence of sudden infant death syndrome (SIDS), given that SIDS is associated with failed autoresuscitation and reduced brainstem 5-HT.
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